Table 4.

The MR estimates, test of heterogeneity and test of pleiotropy of exposures on HCC based on BBJ.

Exposure	NSNP	MR methodology	Effect Estimates HCC				Test of heterogeneity		Test of pleiotropy
			OR	95%LCI	95%UCI	P value	Cochrane Q test	Phetero- geneity	MR Egger intercept	Ppleio- tropy
TG	32	IVW	1.114	0.911	1.362	0.292	59.760	0.001
		MR Egger	1.014	0.649	1.584	0.952	59.198	0.001	0.008	0.597
		Weighted median	1.059	0.758	1.479	0.738
TC	43	IVW	0.903	0.680	1.200	0.482	61.154	0.028
		MR Egger	1.012	0.415	2.465	0.980	61.044	0.023	0.019	0.788
		Weighted median	0.740	0.473	1.158	0.188
HDL-C	49	IVW	0.950	0.817	1.111	0.519	58.691	0.122
		MR Egger	1.053	0.781	1.419	0.736	47	0.118	−0.006	0.600
		Weighted median	0.984	0.759	1.276	0.904
LDL-C	27	IVW	0.917	0.729	1.155	0.462	31.142	0.223
		MR Egger	1.050	0.702	1.570	0.816	30.276	0.214	−0.012	0.406
		Weighted median	1.075	0.747	1.549	0.666

Notes: NSNP is the number of single nucleotide polymorphism; The odds ratio (OR) is per 1 SD increase; 95%LCI is the lower limit of 95% confidence interval; 95%UCI is the upper limit of 95% confidence interval; P value is the p-value of OR; Pheterogeneity is the p-value of Cochrane's Q value in heterogeneity test; Ppleiotropy is the p-value of MR-Egger intercept.