Table 2.

Binding affinities, polar bonding, and hydrophobic interactions of Alg-4-AP₃ against the proposed target receptors.

Target	Binding energy (kcal/mol)	Polar bonding	Hydrophobic interactions
EGFR	−6.9	Met793	Leu 718, Val 726, Ala 743, Lys 745, Glu 762, Leu 788, Thr790, Leu 792, Gly 796 and Leu 844
HER2	−7.4	Pro 761, Lys 765, Glu 764, Arg 966 and Glu 975	Lys 957, Cys 965, Pro 967 and Glu 971
VEGFR 2	−6.5	Thr859, Thr861, Glu 917 and Glu 1038	Leu 836, Gly 837, Lys 838, Pro 839, Asp 857, Arg 863, Ser 1037 and Lys 1043