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. 2023 Jun 21;15(6):e40742. doi: 10.7759/cureus.40742

Table 4. Selection of ongoing OVs in clinical trials (with or without co-therapy) obtained from Clinicaltrials.gov.

OV: oncolytic virus, P: phase, AdV: adenovirus, TNF: tumor necrosis factor, IL-12: interleukin 12, ICI: immune checkpoint inhibitor, PTD: protein transduction domain, NETs: neuroendocrine tumors, CD: cytosine deaminase, HSV: herpes simplex virus, TK: thymidine kinase, PC: pancreatic cancer, IFN: Interferon, GM-CSF: granulocyte-macrophage colony stimulating factor, FLT3LG: Fms-related tyrosine kinase 3 ligand, CCL4: chemokine ligand 4, CYP2B1: cytochrome p450 2B1, LTs: liver tumors, MV: measles virus, NIS: sodium iodide symporter, ATRT: atypical teratoid rhabdoid tumor, NAP: neutrophil activating protein, BC: breast cancer, GUCB: glucuronidase beta, B-gal: beta-galactosidase, GFP: green fluorescent protein, LC: lung cancer, NSCLC: non-small cell lung cancer, MM: multiple myeloma, BTs: brain tumors, GP: p-glycoprotein, CRC: colorectal cancer.  

Viral species Variant Genetic modification Condition Co-therapy P Identification number
AdV TILT-123 TNF-B and IL-2 Ovarian cancer ICI I NCT05271318  
AdVince Chromogranin A and PTD [118] NETs NA I/IIa NCT02749331
Theragene   CD and HSV-1 TK [119] PC Radiotherapy IIa NCT04739046
YSCH-01 L-IFN Advanced solid tumors NA I NCT05180851
NG-641 FAP-TAc and CXCL9/CXCL10/IFN-alpha Metastatic cancers Chemotherapy or ICI I NCT04053283
HSV G207 Deletion of γ134.5 [120]     Cerebellar tumors Radiotherapy I NCT03911388
OH2 GM-CSF Advanced PC NA Ib/II NCT04637698
ONCR-177 IL-12, FLT3LG, CCL4 [121] Advanced cutaneous and solid cancers ICI I NCT04348916
rRp450   CYP2B1 and Deletion of ICP6 [122] Primary LTs NA I NCT01071941
MV MV-NIS NIS Recurrent medulloblastoma and ATRT Surgery I NCT02962167
MV-s-NAP NAP Metastatic BC NA I NCT04521764
VV GL-ONC1 GUCB, B-gal and GFP [123] LC and mesothelioma NA I NCT01766739
MVA-MAGEA3 MAGE-A3 NSCLC OV: ChAdOx-1-MAGEA3-NYESO, chemotherapy and ICI   I/II NCT04908111
  JX-594 GM-CSF and B-gal [124] Advanced BC and sarcoma Chemotherapy I/II NCT026330368
Reovirus Reolysin NA Relapsed or refractory MM Chemotherapy I NCT02101944
Relapsed or refractory BTs Recombinant GM-CSF I NCT02444549
NDV MEDI5395 GM-CSF [125] Advanced solid tumors Durvalumab   I NCT03889275
VSV VSV-hIFNbeta-NIS IFN-beta and NIS Stage IV or Recurrent Endometrial cancer With or without chemotherapy I NCT03120624
  VSV-GP128 GP Stage IV CRC immunotherapy vaccines I/II NCT04046445