Skip to main content
. 2023 Jun 10;9(6):e17194. doi: 10.1016/j.heliyon.2023.e17194

Fig. 5.

Fig. 5

The effects of MMP1 on PC cells and rescue experiment. (A–B) The proliferation of AsPC-1 and MiaPaCa-2 cells after MMP1 knockdown was detected by CCK-8 assay. (C–D) The survival rates of AsPC-1 and MiaPaCa-2 cells treated with different concentrations of gemcitabine were calculated based on the CCK-8 assay. (E) The migration capacity of PC cells was demonstrated by the Transwell assay. (F–H) MMP1 overexpression in PRKRA knockdown cells rescued the proliferation, chemoresistance, and migration. (I–K) The proliferation, chemoresistance, and migration were decreased by Si-MMP1 in PRKRA overexpression cells. (Scale bar = 100 μm; *p value < 0.05; **p value < 0.01; ***p value < 0.001; ****p value < 0.0001.)