Table 5.
Serum levels of IL-23 and IL-27 in relation to IL-27 and IL-23 gene polymorphisms of RRMS patients.
| SNPs | Genetic model | Genotypes | Mean ± SD | p-value |
|---|---|---|---|---|
| IL-23 (pg./ml) | ||||
| T4730C (IL-27) | Codominant | TT (n = 36) | 186.5 ± 107.5 | 0.950 |
| TC (n = 24) | 178.5 ± 75.5 | |||
| CC (n = 7) | 183.8 ± 71.5 | |||
| Dominant | TT (n = 36) | 186.5 ± 107.5 | 0.762 | |
| TC + CC (n = 31) | 179.7 ± 73.5 | |||
| A964G (IL-27) | Codominant | AA (n = 15) | 218.9 ± 121.1 | 0.086 |
| AG (n = 36) | 185.3 ± 77.7 | |||
| GG (n = 16) | 145.6 ± 85.2 | |||
| Dominant | AA (n = 15) | 218.9 ± 121.1 | 0.184 | |
| AG + GG (n = 52) | 173.1 ± 81.4 | |||
| R381Q (IL-23) | Codominant | GG (n = 64) | 188.5 ± 91.1 | 0.035* |
| AG (n = 3) | 73.4 ± 59.9 | |||
| IL-27 (pg./ml) | ||||
| T4730C (IL-27) | Codominant | TT (n = 36) | 21.1.5 ± 5.7 | 0.934 |
| TC (n = 24) | 20.0 ± 3.8 | |||
| CC (n = 7) | 17.9 ± 3.8 | |||
| Dominant | TT (n = 36) | 21.1 ± 5.7 | 0.198 | |
| TC + CC (n = 31) | 19.5 ± 3.9 | |||
| A964G (IL-27) | Codominant | AA (n = 15) | 20.2 ± 5.4 | 0.314 |
| AG (n = 36) | 21.1 ± 5.3 | |||
| GG (n = 16) | 18.8 ± 3.5 | |||
| Dominant | AA (n = 15) | 20.2 ± 5.4 | 0.875 | |
| AG + GG (n = 52) | 20.4 ± 4.9 | |||
| R381Q (IL-23) | Codominant | GG (n = 64) | 20.3 ± 5.0 | 0.940 |
| AG (n = 3) | 20.6 ± 4.6 | |||
SD = sample standard deviation; p-values were obtained from Student-t test with equal variances or Welch Two Sample t-test or ANOVA.