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. Author manuscript; available in PMC: 2024 Jan 1.
Published in final edited form as: Tuberculosis (Edinb). 2022 Dec 27;138:102302. doi: 10.1016/j.tube.2022.102302

Figure 1. Overview of vaccine strategies and experimental design.

Figure 1.

(A) Schematic of ID91 replicon RNA (repRNA) formulated in a Lipid InOrganic Nanoparticle (LION™) delivery system. (B) Prime/boost vaccine strategies received by each group. (C) Timeline of immunizations and M. avium 2-151 smt aerosol challenge. Experimental samples were collected at two time-points: D35 (one week post boost immunization) and D96 (six weeks post M. avium challenge).