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. Author manuscript; available in PMC: 2024 Jan 1.
Published in final edited form as: Tuberculosis (Edinb). 2022 Dec 27;138:102302. doi: 10.1016/j.tube.2022.102302

Figure 2. Heterologous RNA prime/protein boost vaccine strategy drives a robust systemic proinflammatory response both post-boost and post- M. avium challenge.

Figure 2.

Circulating proinflammatory cytokine levels were measured in serum samples collected one week post boost immunization and six weeks post M. avium challenge. (A-H) Concentration of IFN-γ, TNF-α, IL-1β, IL-2, IL-6, KC/GRO, IL-10, and IL-5 (measured in pg/mL) at both time points. Bars show mean ± SEM, dots represent individual mice, n = 3–4/group. Asterisks indicate statistical significance compared to the saline alone group, where **p<0.01, ***p < 0.001, and ****p < 0.0001 using two-way ANOVA with Dunnett’s multiple comparisons test.