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. Author manuscript; available in PMC: 2024 Jan 1.
Published in final edited form as: Tuberculosis (Edinb). 2022 Dec 27;138:102302. doi: 10.1016/j.tube.2022.102302

Figure 3. Heterologous RNA prime/protein boost vaccine strategy induces ID91 and Ag85B antigen-specific humoral immune responses post-boost and post M. avium challenge.

Figure 3.

Serum samples were collected one week post boost immunization and six weeks post M. avium challenge and were evaluated for: (A-C) ID91 antigen specific Total IgG (A), IgG1 (B), and IgG2c (C) responses; (D-F) Ag85B-specific Total IgG (D), IgG1 (E), and IgG2c (F) responses. Log10 endpoint titer (EPT) is shown (LOD = limit of detection). Bars show mean ± SEM, dots represent individual mice, n = 3–4/group. Asterisks indicate statistical significance compared to saline alone cohort, where **p < 0.01, ***p < 0.001, and ****p < 0.0001 using two-way ANOVA with Dunnett’s multiple comparisons test.