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. Author manuscript; available in PMC: 2024 Jan 1.
Published in final edited form as: Tuberculosis (Edinb). 2022 Dec 27;138:102302. doi: 10.1016/j.tube.2022.102302

Figure 7. All prophylactic prime/boost vaccine strategies decrease lung immunopathology in Beige mice post challenge with M. avium.

Figure 7.

(A-F) Representative images of accessory lung lobes from beige mice immunized with saline (A), BCG (B)v, repRNA-ID91 (C), ID91+GLA-SE (D), repRNA-ID91 prime/ID91+GLA-SE boost (E), or ID91+GLA-SE prime/repRNA-ID91 boost (F) after H&E staining for pulmonary lesions (dark purple). (G) Bars show mean ± SEM percent lesion area, dots represent individual mice, n = 7/group. Asterisks indicate statistical significance, where ****p < 0.0001 using one-way ANOVA with Dunnett’s multiple comparisons test.