eTable 2.

Detailed search strategy

Key word

Search stratagy

Key word

("corneal collagen cross-linking"):ti,ab,kw OR ("corneal collagen crosslinking"):ti,ab,kw OR ("corneal crosslinking"):ti,ab,kw OR ("collagen crosslink*"):ti,ab,kwOR ("collagen crosslinking"):ti,ab,kw (Word variations have been searched) ("collagen crosslinkage"):ti,ab,kw OR ("corneal crosslinkage"):ti,ab,kw OR ("corneal cross-linking"):ti,ab,kw OR ("C3-R Corneal cross-linking"):ti,ab,kw OR ("C3R corneal cross-linking"):ti,ab,kw (Word variations have been searched) ("Holcomb C3-R cross linking"):ti,ab,kw OR (CXL):ti,ab,kw OR (CCL):ti,ab,kw OR (C3R):ti,ab,kw OR ("corneal CXL"):ti,ab,kw (Word variations have been searched) #1 OR #2 OR #3 ("progressive keratoconus"):ti,ab,kw OR ("corneal ectasia"):ti,ab,kw OR ("conical cornea"):ti,ab,kw OR ("keratoconus"):ti,ab,kw (Word variations have been searched) MeSH descriptor: [Keratoconus] explode all trees #5 OR #6 #4 AND #7 Limit in trials

CXL=Corneal collagen cross-linking, CCL=Central corneal thickness