Table 2.

Regression analysis relating 1 standard deviation increment in plasma amyloid β (Aβ) Aβ40, Aβ42, and Aβ42/Aβ40 ratio in relation to global Aβ derived from PET imaging. Global brain Aβ was examined continuously by linear regression and categorically by logistic regression. Global Aβ positivity was determined by k-means (SUVR = 1.34). Standardized betas and odds ratios are reported. Model 1 is unadjusted. Model 2 adjusts for age, and sex. Model 3 adjusts for age, sex, and APOE-ε4 carrier status.

			Model 1		Model 2		Model 3
	No.	Aβ Outcome	β (95% CI) OR (95% CI)	p-value	β (95% CI) OR (95% CI)	p-value	β (95% CI) OR (95% CI)	p-value
β (95% CI) Global Aβ SUVR
Aβ40			0.03 (−0.08, 0.13)	0.60	0.02 (−0.08, 0.13)	0.67	0.01 (−0.09, 0.11)	0.86
Aβ42	345		−0.09 (−0.20, 0.02)	0.095	−0.09 (−0.20, 0.01)	0.080	−0.08 (−0.18, 0.02)	0.14
Aβ42/Aβ40			−0.16 (−0.27, −0.06)	0.0028	−0.16 (−0.26, −0.05)	0.0031	−0.13 (−0.23, −0.03)	0.013
OR (95% CI) Aβ Positivity by k-means (SUVR = 1.34)
Aβ40			0.99 (0.64, 1.40)	0.94	0.96 (0.62, 1.37)	0.84	0.94 (0.62, 1.33)	0.74
Aβ42	345	Positive	0.68 (0.45, 1.01)	0.060	0.68 (0.45, 1.01)	0.060	0.69 (0.44, 1.06)	0.093
Aβ42/Aβ40			0.59 (0.41, 0.86)	0.0047	0.61 (0.42, 0.88)	0.0081	0.59 (0.38, 0.91)	0.016