. 2023 Jul 21;18(7):e0288780. doi: 10.1371/journal.pone.0288780

Table 8. Solubility of cephapirin in selected milk vehicles at 38°C and nifedipine at RT or 38°C (n = 3) (mean ± SD).

Drug	Solubility (mg/mL) ^a
Drug	Reconstituted Whole Milk Powder (Nestle)		Raw Milk
Nifedipine RT	0.0334 ± 0.0067		0.0120 ± 0.0014
Nifedipine 38°C	0.0947 ± 0.0143		0.0396 ± 0.0043
Cephapirin Sodium ^b	> 500		> 500
Cephapirin Benzathine^c	Lot 1	Lot 2	0.706 ± 0.021
Cephapirin Benzathine^c	0.740 ± 0.005	0.762 ± 0.028	0.706 ± 0.021

a. Solubility values are expressed as the free form of cephapirin, not the salt form.

b. Due to the high solubility of cephapirin sodium and limited availability of drug substance, each value was obtained from only one sample.

cv per lot of reconstituted whole milk.