Figure 3.

Differential gene expression. (A) Comparison of immune cell populations between children with MtD and controls via UMAP clustering. Red box = B cells and plasma cells. (B) B cell subpopulation analyses via UMAP clustering. (C) Top 5 gene ontology terms for overall differential gene expression profiles. (D) Table of Log₂FC changes for differentially expressed genes (P < 0.05). Green = down, Red = UP. (E) Feature plot of MTRNR2L8 expression across immune cell subsets. (F) Percent of cells that were positive for MTRNR2L8 within the identified clusters. (G) MTRNR2L8 Log₂FC within the individual immune subsets.