Figure 6.

Viral exposome defined via AVARDA. Serum was analyzed from controls (N = 16) and MtD (N = 16). To account for overrepresentation and antigenic overlap, AVARDA was used to deconvolute the antibody repertoire and make viral exposure calls. By alignment of all library peptides to each other and all human viruses, AVARDA provides a probabilistic calculation of infection. A viral exposure was called positive if the FDR < 0.05. (A) Top 10 viral exposures. (B) Top 30 viral species are listed. Heat map of false discovery rates was constructed, in each row, each box represents an individual. MtD, mitochondrial disease; FDR, false discovery rate.