Fig. 10. The astrocytic TRPA1 plays a protective role in CCH-induced VCI by producing LIF.

A schematic summary of the role and mechanism of TRPA1 during CCH. TRPA1 stimulation in astrocytes under CCH increases LIF production by increasing Ca²⁺ influx and inducing p38-MAPK phosphorylation and promotes myelination. ROS, reactive oxygen species.