Skip to main content
. 2023 Jul 21;9(29):eadh0102. doi: 10.1126/sciadv.adh0102

Fig. 2. Cinnamaldehyde (CA), a TRPA1 agonist, attenuates BCAS-induced cognitive impairment and white matter injury.

Fig. 2.

(A) Experimental time course for CA administration and the NORT. (B and C) Discrimination indexes for exploring the blue quadrangular object during the training session (B) and the wooden ball, i.e., novel object, during the test session (C) on postoperative day 28. (D and E) Representative images of myelin staining in the corpus callosum (D) and summarized data for relative myelin density (E) on postoperative day 28. Values are means ± SEM. Scale bar, 100 μm. (B) and (C) n = 15 (vehicle), n = 7 to 14 (CA); (E) n = 16 to 17 (vehicle), n = 7 to 16 (CA). *P < 0.05 and ***P < 0.001 for two-tailed unpaired Student’s t test [(C) vehicle and (E) vehicle]. *P < 0.05 and **P < 0.01 for one-way ANOVA with Tukey’s post hoc test [(C) CA and (E) CA]. i.p., intraperitoneal administration; N.S., not significant.