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. 2023 Jul 21;9(29):eadh0102. doi: 10.1126/sciadv.adh0102

Fig. 4. BCAS induces cognitive impairment and white matter injury on day 14 in astrocyte-TRPA1-cKO mice.

Fig. 4.

(A) A schematic for obtaining tamoxifen-inducible astrocyte-TRPA1-cKO and control mice. (B) The experimental time course for tamoxifen administration and the NORT. (C and D) Discrimination indexes for exploring the blue quadrangular object during the training session (C) and the wooden ball, i.e., novel object, during the test session (D) on day 14. (E and F) Representative images of myelin staining in the corpus callosum (E) and summarized data for relative myelin density (F) on day 14. Values are means ± SEM. Scale bar, 100 μm. (C) and (D) n = 7 to 13; (F) n = 5 to 11. *P < 0.05 for two-way ANOVA with Bonferroni’s post hoc test (D) and (F).