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. 2023 Jul 21;9(29):eadg5301. doi: 10.1126/sciadv.adg5301

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Fig. 3. — (A) Representative flow cytometry plots of memory B cells (CD19⁺ IgD⁻) stained with ancestral (Wuhan Hu-1) and BA.1 or BA.2 fluorescent spike probes, from two individuals with BA.1 breakthrough infection and two with BA.2 breakthrough infection at around days 10 and 30 after symptom onset. APC, allophycocyanin. (B) Frequencies of memory B cells (CD19⁺ IgD⁻) from BA.1 breakthrough subjects (red) and BA.2 breakthrough subjects (blue) that are cross-reactive with Wuhan Hu-1 and BA.1/BA.2 spike (top) or memory B cells that only recognize BA.1/BA.2 spike (bottom) over time. (C) Frequencies of activated memory B cells (CD21⁻ CD27⁺) that are cross-reactive or specific for BA.1/BA.2 spike from BA.1 breakthrough subjects (red) and BA.2 breakthrough subjects (blue). (D) Antibody isotype distribution of cross-reactive or BA.1/BA.2 spike monospecific memory B cells.