Fig. 7. FADS2 expression is increased in aldosterone-producing adenomas.

(A) FADS2 expression was determined in nontumorous adrenocortical tissue from pheochromocytoma patients (n = 6 patients), non-active adenomas (n = 10 patients), and aldosterone-producing adenomas (Conn adenomas) (n = 30 patients) by qPCR using 18S as a housekeeping gene. (B) Pre-operative aldosterone plasma levels in the same patients as in (A) were measured by LC-MS/MS. (C) Correlation of FADS2 with STAR expression in aldosterone- and cortisol-producing adrenocortical adenomas from 30 and 7 patients, respectively. FADS2 and STAR expression was determined by qPCR using 18S as a housekeeping gene. Data in (A) and (B) are presented as mean ± SEM. *P < 0.05; **P < 0.01; ****P < 0.0001