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. 2023 Jul 7;14:1179534. doi: 10.3389/fmicb.2023.1179534

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Copyright © 2023 Tanaka, Tanigawa, Song, Komatsu, Kuriki, Tanaka, Fukudo, Urano and Fukuda.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Differentiated enzyme activity in IBS-n fecal samples. Certain probes were differentially hydrolyzed in fecal samples of IBS-n patients. LEfSe analysis shows probes with | discriminant score | > 2.5, p < 0.05. Probes that were less actively cleaved in IBS-n patient fecal samples are shown in blue, and probes more actively cleaved in IBS-n patient fecal samples are shown in red. The alphabets represent amino acid residues. d = D-aspartyl, s = D-Serinyl, 8 = sarcosinyl, gGlu = γ-glutamic acid, Mo = methionyl-S-oxide, Ac = acetyl. For enzyme abbreviations, please refer to Supplementary Figure S1.