Table 1. Transcriptional response profiles of steroidogenic genes for estrogen synthesis in H295R cells exposed to benzalkonium chloride (BAC).
| Gene | BAC exposure | |||
|---|---|---|---|---|
| 0 mg/L | 0.5 mg/L | 1.0 mg/L | 1.5 mg/L | |
| HMGR | 1.01±0.02 | 0.96±0.23 | 1.03±0.22 | 1.24±0.36 |
| StAR | 1.02±0.03 | 1.12±0.31 | 0.91±0.34 | 1.10±0.27 |
| CYP11A | 1.00±0.02 | 1.28±0.24 | 1.27±0.30 | 1.41± 0.36 |
| CYP17 | 0.98±0.15 | 1.15±0.25 | 1.18±0.27 | 1.22±0.32 |
| CYP19A | 1.00±0.06 | 1.42±0.52 | 1.72±0.34* | 2.01±0.37** |
| 3β-HSD2 | 1.01±0.05 | 1.28±0.21 | 1.42±0.29* | 1.78±0.31** |
| 17β-HSD1 | 1.02±0.05 | 1.37±0.16* | 1.50±0.18** | 2.32±0.13** |
| 17β-HSD4 | 1.02±0.08 | 1.33±0.16* | 1.70±0.27** | 2.14±0.19** |
The mRNA expression is reported as the means±SD fold change compared to the vehicle controls (n=3). *P<0.05, **P<0.01 compared to the vehicle controls (0 mg/L) (ANOVA).