Table 4.
Univariable and multivariable analysis for mortality following LT hospital discharge
| Factor | Univariable HR (95% CI) | P value | Multivariable aHR (95% CI) | P value |
|---|---|---|---|---|
| Prior decompensation | 2.48 (1.28–4.80) | 0.007 | 2.71 (1.61–4.59) | <0.001 |
| Age, per year | 1.02 (0.98–1.06) | 0.37 | — | — |
| Male | 0.81 (0.65–1.00) | 0.05 | — | — |
| Non-White race/ethnicity | 2.47 (1.34–4.53) | 0.004 | 2.51 (1.40–4.50) | 0.002 |
| Insurance | ||||
| Medicare (vs private) | 1.28 (0.41–4.06) | 0.67 | — | — |
| Medicaid (vs private) | 1.14 (0.75–1.74) | 0.54 | — | — |
| Body mass index | 0.98 (0.93–1.03) | 0.44 | — | — |
| Renalreplacement therapy | 1.32 (0.76–2.29) | 0.32 | — | — |
| MELD-Na | 0.93 (0.89–0.98) | 0.004 | — | — |
| On ventilator | 1.36 (0.32–5.71) | 0.68 | — | — |
| Overt hepatic encephalopathy | 0.82 (0.43–1.60) | 0.57 | — | — |
| Days of abstinence | 1.00 (1.00–1.01) | 0.12 | — | — |
| Married or significant other | 0.52 (0.15–1.78) | 0.30 | — | — |
| History of psychiatric disease | 1.85 (0.92–3.71) | 0.08 | — | — |
| On medications for psychiatric disease | 2.74 (1.59–4.71) | <0.001 | 2.73 (1.18–6.33)a | 0.02 |
| Current smoker | 1.40 (0.97–2.01) | 0.08 | — | — |
| Current marijuana | 0.86 (0.65–1.15) | 0.32 | — | — |
| History of illicit drug use | 1.10 (0.46–2.60) | 0.84 | — | — |
| History of failed rehab attempts | ||||
| 1 only (vs none) | 2.24 (0.85–5.89) | 0.10 | — | — |
| ≥ 2 (vs none) | 2.71 (1.34–5.50) | 0.006 | — | — |
| Family history of alcoholuse disorder | ||||
| Immediate family (vs none) | 1.20 (0.29–5.06) | 0.80 | — | — |
| Extended family only | 0.64 (0.19–2.15) | 0.47 | — | — |
| Employment immediately before presentation | 0.59 (0.28–1.23) | 0.16 | — | — |
| Legal history (e.g., DUI and custody loss because of alcohol) | ||||
| 1 only (vs none) | 0.92 (0.18–4.59) | 0.91 | — | — |
| ≥2 (vs none) | 1.14 (0.35–3.68) | 0.83 | — | — |
| >10 alcoholunits per day | 1.38 (0.55–3.45) | 0.49 | — | — |
| >15 years of heavy drinking | 0.73 (0.34–1.56) | 0.42 | — | — |
| Harmfulalcoholuse after LT | 3.31 (1.49–7.35) | 0.003 | 3.02 (1.21–7.51) | 0.02 |
DUI, driving under the influence; HR, hazard ratio; LT, liver transplantation; MELD-Na, Model for End-Stage Liver Disease-Sodium score.
a
On medications for psychiatric disease and history of psychiatric disease were co-linear, thus only medications for psychiatric disease was included in the multivariable model given its higher association.