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. 2023 Jul 11;14:1089664. doi: 10.3389/fimmu.2023.1089664

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Copyright © 2023 Schaier, Morath, Wang, Kleist, Opelz, Tran, Scherer, Pham, Ekpoom, Süsal, Ponath, Kälble, Speer, Benning, Nusshag, Mahler, Pego da Silva, Sommerer, Hückelhoven-Krauss, Czock, Mehrabi, Schwab, Waldherr, Schnitzler, Merle, Schwenger, Krautter, Kemmner, Fischereder, Stangl, Hauser, Kälsch, Krämer, Böhmig, Müller-Tidow, Reiser, Zeier, Schmitt, Terness, Schmitt and Daniel

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Survival rates in MIC patients compared to transplanted controls. (A) Overall graft survival in MIC patients was not significantly different from survival in transplanted controls. One transplanted control patient died on post-operative day 531 from severe infectious complications including mucormycosis caused by Rhizopus microsporus. (B) None of the 10 MIC patients but 5 of 15 transplanted control patients developed de novo donor-specific human leukocyte antigen antibodies (dnDSA) against HLA-A, -B, -DR, or -DQB antigens at a cutoff of 1,000 MFI. (C) Opportunistic infection-free survival (i.e., no CMV replication >1.000 IU/mL, no BKV replication >10.000 copies/mL, no other opportunistic infections) was significantly higher in MIC patients compared to transplanted controls. The log rank P value is given for the comparison of MIC (total cohort) versus transplanted controls.