Table 1.
Summary of the demographic data, clinical, and microbiological characteristics for the seven cases of C. fetus infection.
| Cases | Sex/ age | Underlying condition | Clinical signs | Origin of C. fetus isolates | NGS sequencing of the strain/origin | Secondary localization | Outcomes |
|---|---|---|---|---|---|---|---|
| #1 | F/78 | Cardiopathy, polymedicationa ≥ 5, shoulder prosthesis, pacemaker | Fever, diarrhea, prosthetic shoulder pain | Blood cultureb, stoolsb* | Yes/blood culture Genome ID**: 1 | Shoulder Prosthesis | Favorable, 12w clarithromycin after amoxicillin |
| #2 | F/88 | Breast cancer, ADL 3.5/6, polymedicationa, diabetes, hip replacement, pacemaker | Fever, diarrhea, prosthetic hip collection | Blood cultureb, hip collectionc and stoolsc | Yes/blood culture Genome ID**: 2 | Hip prosthesis | Favorable, 12w ciprofloxacin after amoxicillin and surgical debridement |
| #3 | F/79 | ADL 3/6, hip replacement, polymedicationa, penicillin allergy | Fever, diarrhea | Blood cultureb with Listeria co-infection, stoolsc | Yes/blood culture Genome ID**: 3 | None | Favorable with ciprofloxacin + Sulfamethoxazole-Trimethoprim |
| #4 | F/77 | ADL 6/6, cervical arthrodesis | Fever, diarrhea | Blood cultureb, stoolsd | Yes/2 strains: blood culture and stools Genome ID**: 4A, 4B | None | Favorable without antibiotic |
| #5 | F/90 | ADL 6/6, Hip Zimmer Natural Nail, aortic prosthesis | Diarrhea without fever | Stoolsc | No | None | Favorable without antibiotic |
| #6 | F/70 | ADL 3/6, Hematologic cancer with chemotherapy, diabetes | Diarrhea without fever | Blood cultureb | Yes/2 strains from blood culture taken at different times Genome ID**: 6A, 6B | None | Favorable, 1w ciprofloxacin after amoxicillin |
| #7 | F/84 | ADL 6/6, knee and hip replacement | Fever, diarrhea | Stoolsc | No | None | Favorable without antibiotic |
Age is indicated in year.
ADL, Activities of Daily Living; F, female; max. T°C, maximal temperature degree Celsius; NGS, next-generation sequencing; w, week.
aPolymedication ≥ 5 long-term treatment.
bClassic bacteriological culture.
cDetection of C. fetus only by specific PCR.
dDetection by specific PCR and culture.
*This C. fetus isolate was not sequenced.
**Genome ID: Genome identity of C. fetus strain as shown in Figure 1.