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. Author manuscript; available in PMC: 2023 Jul 21.
Published in final edited form as: Nat Mach Intell. 2022 Nov 15;4(11):1017–1028. doi: 10.1038/s42256-022-00561-w

Fig. 5 |. Evaluating gMVP and other published methods in classifying pathogenetic and neutral variants, and in predicting GOF and LOF variants in ion-channel genes.

Fig. 5 |

a, Comparison of ROC curves in classifying pathogenic variants and neutral variants. gMVP-TL1 denotes the model further trained on the pathogenetic and neutral variants in SCNxA genes starting from the weights of the original gMVP model. b, Comparison of ROC curves in classifying GOF and LOF variants. gMVP-TL2 denotes the model further trained on GOF and LOF variants starting from the weights of the original gMVP model.