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. Author manuscript; available in PMC: 2023 Jul 21.
Published in final edited form as: Nat Cardiovasc Res. 2022 Dec 12;1(12):1174–1186. doi: 10.1038/s44161-022-00175-w

Fig. 1 |. Atherosclerotic plaque formation and vascular inflammation in mice lacking platelet sGC.

Fig. 1 |

a–c, Atherosclerotic plaque formation as assessed by aortic root histology (a), aortic en face ORO staining (b), and monocyte and macrophage content (c) in 12 (b: 8) Pf4-Cre+Gucy1b1LoxP/LoxPLdlr−/− mice compared to 14 (b: 9) Pf4-Cre+Gucy1b1+/LoxPLdlr−/− mice that were fed a Western diet for 10 weeks. Two-sided unpaired t-test. d, Leukocyte adhesion to atherosclerotic plaques in n = 13 Pf4-Cre+Gucy1b1LoxP/LoxPLdlr−/− mice compared to n = 11 Pf4-Cr e+Gucy1b1+/LoxPLdlr−/− mice that were fed a Western diet for 6 weeks to induce atherosclerotic plaque formation. Two-sided unpaired t-test. e, Quantification of vascular inflammation by flow cytometry analysis of aortic cell suspensions of Pf4-Cre+Gucy1b1LoxP/LoxPLdlr−/− mice compared to Pf4-Cre+Gucy1b1+/LoxPLdlr−/− mice (n = 11 per group). Two-sided Mann–Whitney U-test. Each symbol represents one independent animal. Data are the mean ± s.e.m.