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. 2023 Jul 5;12:e83385. doi: 10.7554/eLife.83385

Figure 7. HLHS CHCHD3 and CHCHD6 family-based gene interaction screen reveals three hits.

Figure 7.

(A) A Hand4.2-Gal4, tdtK; Chchd3/6RNAiC1 sensitizer line show reduced fractional shortening at 25ºC, which is no longer significant at 21ºC. Unpaired two-tailed t-test, ****p≤ 0.0001; error bars represent SEM. (B) Genetic interaction of Chchd3/6 and prioritized HLHS candidates. Two-way ANOVA with Tukey’s multiple comparisons test, only statistical comparisons between the same RNAi lines are shown; ***p≤ 0.001, ****p≤ 0.0001; error bars represent SEM. (C) Functional overview of human and Drosophila orthologs. KD of Ckd12 with Chchd3/6 KD led to increased lethality of eclosed flies by 1 week-of-age.

Figure 7—source data 1. Functional overview of human and Drosophila orthologs.
KD of Ckd12 with Chchd3/6 KD led to increased lethality of eclosed flies by 1 week-of-age.