Table 1. Linear mixed-effects regression: Results for fluid extraction experiment.
Fixed effects coefficient estimates are given. Number of observations: 15775; embryos n=23; Fixed effects coefficients: 12; Random effects coefficients 69; Covariance parameters: 7. Regression formula: AAV ~1 + Group*LR +Group*PA +Group*Time + (1+Group | EmbryoID). Results relate to Figure 2D–E; *** indicates p<0.001; ** indicates p<0.01; * indicates p<0.05.
| Name | Estimate | Lower CI | Upper CI | p-value |
|---|---|---|---|---|
| (Regression line intercept) | 0.2515 | 0.20762 | 0.29544 | 3.8408E-29 *** |
| No defects group | –0.032775 | –0.12321 | 0.05766 | 0.47748 |
| Defects group | –0.12728 | –0.18434 | –0.070215 | 1.2396E-05 *** |
| Left-right axis | 0.0042934 | –0.0092686 | 0.019363 | 0.57655 |
| Posterior-anterior axis | 0.16131 | 0.14636 | 0.17626 | 6.285E-98 *** |
| Somite stage | 0.02145 | 0.012091 | 0.030809 | 7.0847E-06 *** |
| Interaction of no defects group and left-right axis | 0.026653 | 0.007577 | 0.04573 | 0.006176 ** |
| Interaction of defects group and left-right axis | –0.0026553 | –0.022753 | 0.017443 | 0.79567 |
| Interaction of no defects group and posterior-anterior axis | 0.033645 | 0.012118 | 0.055171 | 0.0021912 ** |
| Interaction of defects group and posterior-anterior axis | –0.041406 | –0.06219 | –0.020622 | 9.461E-05 *** |
| Interaction of no defects group and somite stage | 0.026635 | 0.014317 | 0.038953 | 2.2637E-05 *** |
| Interaction of defects group and somite stage | 0.013497 | 0.00056621 | 0.026427 | 0.040778 * |