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Incidence of osteoporosis associated with aromatase inhibitors.
| Trial(Ref) | Follow-up time | Enrolled patients |
Design | Osteopenia | Osteoporosis |
|---|---|---|---|---|---|
| NCT00541086 (17) | 60 months | 3697 | Anastrozole | 21% | |
| Exemestane | 22% | ||||
| Letrozole | 22% | ||||
| NCT00301457 (18) | 7 years | 1860 | 6 years anastrozole after 2 to 3 years of tamoxifen | 46.9% | 9.5% |
| 3 years anastrozole after 2 to 3 years of tamoxifen | 42.8% | 9.1% | |||
| NCIC CTG MA.27 (19) | 4.1 years | 7576 | Exemestane | 31% | |
| Anastrozole | 35% |
