Table 1.
Relationship between early onset and development of gastric signet-ring cell carcinoma and the onset age and gender.
| Stage | N (%) | Gender | Age |
|---|---|---|---|
| Male (female) | |||
| Foveal epithelial hyperplasia of gastric mucosa | 164 (45.3) | 101 (61.6), 63 (38.4) | 65 (39.6), 99 (60.4) |
| Proliferative dysfunction of stem cells in proliferative zone | 98 (27.1) | 62 (63.2), 36 (36.7) | 37 (37.8), 61 (62.2) |
| Abnormal proliferation and transformation of stem cells in proliferative zone | 73 (20.2) | 45 (61.4), 28 (38.4) | 27 (37.0), 46 (63.0) |
| Signet-ring-like heterocysts | 12 (3.3) | 8 (66.7), 4 (33.3) | 5 (41.7), 7 (58.3) |
| Micro signet-ring carcinoid lesion | 6 (1.7) | 4 (66.6), 2 (33.3) | 3 (50.0), 3 (50.0) |
| Gastric foveolar-type signet-ring cell carcinoma | 2 (0.6) | 1 (50.0), 1 (50.0) | 1 (50.0), 1 (50.0) |
| Adenocarcinoma with signet-ring cell differentiation | 7 (1.9) | 5 (71.4), 2 (28.6) | 4 (57.1), 3 (42.9) |
| Undifferentiated adenocarcinoma with signet-ring cell differentiation | 3 (0.8) | 2 (66.7), 1 (33.3) | 2 (66.7), 1 (33.3) |
| Mucinous adenocarcinoma with signet-ring cell differentiation | 2 (0.3) | 1 (50.0), 1 (50.0) | 1 (50.0), 1 (50.0) |
| Adenoid adenocarcinoma with signet-ring cell differentiation | 1 (0.3) | 1 (100.0), 0 (0.0) | 1 (100.0), 0 (0.0) |
| Fundus gland adenocarcinoma with signet-ring cell differentiation | 1 (0.3) | 1 (100.0), 0 (0.0) | 0 (0.0), 1 (100.0) |
| Total | 362 | 226 (62.4), 136 (37.7) | 142 (39.2), 220 (60.8) |