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. 2023 Jul 7;14:1201104. doi: 10.3389/fneur.2023.1201104

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Copyright © 2023 Sibarov, Tsytsarev, Volnova, Vaganova, Alves, Rojas, Sanabria, Ignashchenkova, Savage and Inyushin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Arc mediated changes of seizure susceptibility. (1) Elevated Arc expression in epileptic focus weakens external AMPA-mediated excitatory influence. (2) Arc expression also decreases excitatory feedback to inhibitory neurons.