Table 2.

Arc expression in genetic models of epilepsy in mice.

Gene set ID	Title	Structure	Study group(s)	Expression levels*	Differential expression	Measure units
GSE138370 (95)	Changes in calcium homeostasis and gene expression implicated in epilepsy in hippocampi of mice overexpressing ORAI1	Hippocampus	ORAI1 overexpressing group (n = 3) vs. WT** (n = 3)	49.38–90.56	NS	CPM
GSE147466 (96)	Genetic deletion of microRNA-22 blunts the inflammatory transcriptional response to status epilepticus and exacerbates epilepsy in mice	Hippocampus	miR-22-/- (n = 4) vs. WT (n = 4); status epilepticus in both groups	44.47–75.63	Loss of Arc expression in miR-22-/– group (Pagj < 0.023)	FPKM
GSE151742 (97)	Expression of the neuronal tRNA n-Tr20 regulates synaptic transmission and seizure susceptibility	Hippocampus	B6N-n-Tr20-/- (n = 3) vs. B6N WT (n = 3)	66.48–161.59 (ribosomal), 66.58–128.52 (total)	NS	CPM
GSE169481 (98)	Deletion of a non-canonical regulatory sequence causes loss of Scn1a expression and epileptic phenotypes in mice	Hippocampus	heterozygous Scn1a KO (n=3) vs. WT (n = 4)	114.12–209.22	NS	CPM
GSE215425	WWOX P47T loss-of-function mutation induces epilepsy, progressive neuroinflammation, and cerebellar degeneration	Prefrontal cortex	WWOX P47T (loss-of-function mutation induces epilepsy, n = 5) vs. WT (n = 5)	43.70–698.65	NS	CPM
		Parietal cortex		34.47–496.00	NS	CPM
		Hippocampus		34.21–231.61	NS	CPM
		Cerebellum	WWOX P47T (n = 3) vs. WT (n = 4)	18.57–29.26	NS	CPM

^*In control animals.

^**NS, non-significant.