Table 3.
Arc expression in non-genetic models of epilepsy in rat.
Gene set ID | Title | Structure | Study group(s) | Expression levels* | Differential expression | Mea- sure units |
---|---|---|---|---|---|---|
GSE137473 (100) | A systems approach delivers a functional microRNA catalog and expanded targets for seizure suppression in temporal lobe epilepsy | hippocampus | Perforant pathway stimulation (PPS) model (n = 3) vs. Ctrl (n = 3) | 3.59–7.52 | NS* | FPKM |
GSE143555 (101) | RNA sequencing of laser-captured hippocampal deep and superficial CA1 subfields in epilepsy | CA1 | kainic acid-induced status epilepticus (n = 3) and sham control (n = 3 group), deep and superficial CA1 subfields were studied separately | 49,72–67,39 (superficial layer); 63.99–81.32 Ideep layer) | Downregulated in the superficial layer in kainite-treated animals (Padj < 0.0019) | CPM |
GSE173885 (102) | Transcriptome of the audiogenic rat strain and identification of possible audiogenic epilepsy-associated genes | corpora quadrigemina | KM - audiogenic epilepsy rat strain (n = 3), Wistar rat (n = 4); outbred strain from KM rats (n = 4) | 13.12–25.20 | NS | CPM |
GSE178409 | Transcriptomic analysis of dorsal and ventral subiculum after the induction of acute seizures by the electric stimulation of the perforant pathway in rats | subiculum | Ventral and dorsal subiculum, after the induction of acute seizures by electric stimulation (n = 5) and in the control group (n = 5) | 135.44–179.41 (dorsal); 30.91–63.16 (ventral) | Downregulated in dorsal subiculum in treated animals (Padj < 0.0024) | CPM |
GSE193580 | Hippocampus RNA-sequencing of Q808 against PTZ-induced seizure model | hippocampus | Rats were randomly divided into vehicle control group (n = 4), PTZ + vehicle group (n = 5), and PTZ + Q808 group (n = 5) | 35.06–80 | NS | FPKM |
*In control animals.
**NS, non-significant.