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. 2023 Jul 7;14:1201104. doi: 10.3389/fneur.2023.1201104

Table 3.

Arc expression in non-genetic models of epilepsy in rat.

Gene set ID Title Structure Study group(s) Expression levels* Differential expression Mea- sure units
GSE137473 (100) A systems approach delivers a functional microRNA catalog and expanded targets for seizure suppression in temporal lobe epilepsy hippocampus Perforant pathway stimulation (PPS) model (n = 3) vs. Ctrl (n = 3) 3.59–7.52 NS* FPKM
GSE143555 (101) RNA sequencing of laser-captured hippocampal deep and superficial CA1 subfields in epilepsy CA1 kainic acid-induced status epilepticus (n = 3) and sham control (n = 3 group), deep and superficial CA1 subfields were studied separately 49,72–67,39 (superficial layer); 63.99–81.32 Ideep layer) Downregulated in the superficial layer in kainite-treated animals (Padj < 0.0019) CPM
GSE173885 (102) Transcriptome of the audiogenic rat strain and identification of possible audiogenic epilepsy-associated genes corpora quadrigemina KM - audiogenic epilepsy rat strain (n = 3), Wistar rat (n = 4); outbred strain from KM rats (n = 4) 13.12–25.20 NS CPM
GSE178409 Transcriptomic analysis of dorsal and ventral subiculum after the induction of acute seizures by the electric stimulation of the perforant pathway in rats subiculum Ventral and dorsal subiculum, after the induction of acute seizures by electric stimulation (n = 5) and in the control group (n = 5) 135.44–179.41 (dorsal); 30.91–63.16 (ventral) Downregulated in dorsal subiculum in treated animals (Padj < 0.0024) CPM
GSE193580 Hippocampus RNA-sequencing of Q808 against PTZ-induced seizure model hippocampus Rats were randomly divided into vehicle control group (n = 4), PTZ + vehicle group (n = 5), and PTZ + Q808 group (n = 5) 35.06–80 NS FPKM

*In control animals.

**NS, non-significant.