TABLE 1.
Distribution of the virulence genes in 274 invasive Streptococcus dysgalactiae subspecies equisimilis (SDSE) isolates collected in Norway during 2018.
| Function | Gene | Description | GenBank ID | Present n (%) | MGE |
| Adhesion | fnbA | Fibronectin-bind | Z22150 | 0 | – |
| fnbB | Fibronectin-bind | Z29088 | 272 (99) | – | |
| gfba | Fibronectin-bind | U31115 | 123 (45) | – | |
| fbp54 | Fibronectin-bind | L288918 | 274 (100) | – | |
| gapC | Plasminogen-bind | X97788 | 274 (100) | – | |
| PI_1 | Pilus island 1/FCT | – | 274 (100) | – | |
| PI_2 | Pilus island 2 | – | 257 (94) | – | |
| lmb | Cell-adhesion | AB040535 | 273 (99) | – | |
| alp* | Cell-adhesion | VTT08026 | 49 (18) | Yes | |
| bspA | Cell-adhesion | CAD46802 | 121 (44) | Yes | |
| Dissemination | Skc | Streptokinase | K02986 | 273 (99) | – |
| hylD | Hyaluronidase | BAH81156 | 274 (100) | – | |
| sda1 | DNAse | WP032463908 | 0 | Yes | |
| sda2 | DNAse | WP002988811 | 31 (11) | Yes | |
| sdn | DNAse | AAM80016 | 5 (2) | Yes | |
| spd1 | DNAse | NP_268944 | 0 | Yes | |
| spd3 | DNAse | NP_269520 | 10 (4) | Yes | |
| spd4 | DNAse | AAM79702 | 0 | Yes | |
| Immune evasion | scpA | C5a-peptidase | J05229 | 273 (99) | – |
| drsG | AMP-cleave | AB508817 | 70 (26) | – | |
| endoSD | Ig-cleave | KT030921 | 0 | – | |
| endoS2D | Ig-cleave | KT071707 | 1 (1) | – | |
| prg | Ig-binding/Protein G | Y00428 | 273 (99) | – | |
| hasA | Capsule | L20853 | 0 | – | |
| hasB | Capsule | WP009880737 | 0 | – | |
| hasC | Capsule | WP010922799 | 274 (100) | – | |
| Toxin | sagA-H | Streptolysin S | AY033399 | 274 (100) | – |
| slo | Streptolysin O | BAH82508 | 273 (99) | – | |
| speA | Superantigen | WP009880239 | 0 | Yes | |
| speC | Superantigen | AAK33664 | 0 | Yes | |
| speG | Superantigen | AF124499 | 168 (61) | – | |
| speH | Superantigen | AF124500 | 0 | Yes | |
| speI | Superantigen | AF438524 | 0 | Yes | |
| speJ | Superantigen | WP011284554 | 0 | – | |
| speK | Superantigen | WP011054728 | 0 | Yes | |
| speL | Superantigen | WP011017837 | 0 | Yes | |
| speM | Superantigen | WP011017838 | 0 | Yes | |
| speQ | Superantigen | BK010655 | 0 | – | |
| speR | Superantigen | BK010662 | 0 | – | |
| ssa | Superantigen | L29565 | 0 | Yes | |
| smeZ | Superantigen | NP_269959 | 0 | – | |
| Other | sil | Invasive locus | KF188416 | 177 (65) | – |
*Included the genes alp3 and dysalp. MGE, mobile genetic element; FCT, Fibronectin Collagen and T-antigen.