Table 2.
Correlation between KIF23 and related marker genes of immune cells in TIMER.
| Description | Gene markers | STAD | ESCA | ||||||
|---|---|---|---|---|---|---|---|---|---|
| None | Purity | None | Purity | ||||||
| Cor | P | Cor | P | Cor | P | Cor | P | ||
| CD8+ T cell | CD8A | -0.108 | 2.81e-02 | -0.097 | 6.04e-02 | -0.113 | 1.26e-01 | -0.026 | 7.24e-01 |
| CD8B | 0.036 | 4.62e-01 | 0.055 | 2.84e-01 | -0.152 | 3.91e-02 | -0.072 | 3.38e-01 | |
| T cell (general) | CD3D | -0.123 | 1.24e-02 | -0.093 | 7.17e-02 | -0.205 | 5.15e-03 | -0.112 | 1.35e-01 |
| CD3E | -0.138 | 4.96e-03 | -0.105 | 4.12e-02 | -0.233 | 1.43e-03 | -0.13 | 8.13e-02 | |
| CD2 | -0.081 | 9.76e-02 | -0.053 | 3.08e-01 | -0.174 | 1.82e-02 | -0.072 | 3.37e-01 | |
| B cell | CD19 | -0.181 | 2.07e-04 | -0.168 | 1.03e-03 | -0.138 | 6.92e-02 | -0.032 | 6.67e-01 |
| CD79A | -0.29 | 2.06e-09 | -0.276 | 4.59e-08 | -0.171 | 1.96e-02 | -0.084 | 2.63e-01 | |
| Monocyte | CD86 | -0.028 | 5.68e-01 | 0.005 | 9.30e-01 | -0.001 | 9.92e-01 | 0.093 | 2.16e-01 |
| CD115 (CSF1R) | -0.146 | 2.97e-03 | -0.136 | 8.21e-03 | -0.046 | 5.30e-01 | 0.035 | 6.40e-01 | |
| TAM | CCL2 | -0.234 | 1.52e-06 | -0.216 | 2.22e-05 | 0.051 | 4.88e-01 | 0.142 | 5.68e-02 |
| CD68 | -0.002 | 9.67e-01 | 0.012 | 8.22e-01 | -0.08 | 2.77e-01 | -0.05 | 5.02e-01 | |
| IL10 | -0.013 | 7.90e-01 | 0.013 | 7.89e-01 | -0.001 | 9.94e-01 | 0.073 | 3.32e-01 | |
| M1 Macrophage | INOS (NOS2) | 0.178 | 2.62e-04 | 0.18 | 4.38e-04 | -0.12 | 1.03e-01 | -0.139 | 6.26e-02 |
| IRF5 | 0.003 | 9.49e-01 | 0.016 | 7.52e-01 | -0.098 | 1.85e-01 | -0.069 | 3.56e-01 | |
| COX2(PTGS2) | 0.032 | 5.19e-01 | 0.039 | 4.46e-01 | 0.219 | 2.77e-03 | 0.246 | 8.52e-04 | |
| M2 Macrophage | CD163 | 0.029 | 5.61e-01 | 0.044 | 3.97e-01 | -0.084 | 2.55e-01 | -0.009 | 9.00e-01 |
| VSIG4 | -0.093 | 5.86e-02 | -0.08 | 1.20e-01 | -0.039 | 5.95e-01 | 0.037 | 6.18e-01 | |
| MS4A4A | -0.145 | 3.04e-03 | -0.127 | 1.35e-02 | -0.075 | 3.08e-01 | 0.014 | 8.35e-01 | |
| Neutrophils | CD66b (CEACAM8) | 0.169 | 5.26e-04 | 0.175 | 6.16e-04 | -0.093 | 2.07e-01 | -0.048 | 5.21e-01 |
| CD11b (ITGAM) | --0.109 | 22.71e-02 | -0.091 | 7.83e-02 | --0.062 | 24.04e-01 | -0.006 | 9.41e-01 | |
| CCR7 | --0.258 | 1.14e-07 | --0.232 | 55.02e-06 | --0.244 | 7.98e-04 | --0.144 | 55.38e-02 | |
| Natural killer cells | KIR2DL1 | 0.102 | 3.79e-02 | 0.118 | 2.11e-02 | -0.089 | 2.28e-01 | -0.026 | 7.29e-01 |
| KIR2DL3 | 0.104 | 3.47e-02 | 0.121 | 1.81e-02 | -0.081 | 2.72e-01 | -0.055 | 4.67e-01 | |
| KIR2DL4 | 0.185 | 1.54e-04 | 0.213 | 2.95e-05 | -0.089 | 2.27e-01 | -0.035 | 6.41e-01 | |
| KIR3DL1 | 0.024 | 6.24e-01 | 0.013 | 8.02e-01 | -0.128 | 8.29e-02 | -0.069 | 3.57e-01 | |
| KIR3DL2 | 0.05 | 3.13e-01 | 0.068 | 1.88e-01 | -0.042 | 5.70e-01 | 0.018 | 8.08e-01 | |
| KIR3DL3 | 0.122 | 1.27e-02 | 0.126 | 1.38e-02 | -0.087 | 2.40e-01 | -0.097 | 1.97e-01 | |
| KIR2DS4 | 0.055 | 2.60e-01 | 0.068 | 1.86e-01 | -0.01 | 8.95e-01 | -0.007 | 9.21e-01 | |
| Dendritic cell | HLA-DPB1 | -0.205 | 2.79e-05 | -0.18 | 4.16e-04 | -0.232 | 1.48e-03 | -0.15 | 4.41e-02 |
| HLA-DQB1 | -0.119 | 1.50e-02 | -0.085 | 9.65e-02 | -0.212 | 3.71e-03 | -0.135 | 7.04e-02 | |
| HLA-DRA | -0.099 | 4.49e-02 | -0.069 | 1.79e-01 | -0.191 | 9.36e-03 | -0.108 | 1.49e-01 | |
| HLA-DPA1 | -0.127 | 9.83e-03 | -0.1 | 5.15e-02 | -0.181 | 1.37e-02 | -0.109 | 1.45e-01 | |
| BDCA-1(CD1C) | -0.381 | 9.42e-16 | -0.375 | 3.97e-14 | -0.185 | 1.15e-02 | -0.098 | 1.90e-01 | |
| BDCA-4(NRP1) | -0.312 | 1.03e-10 | -0.3 | 2.69e-09 | 0.128 | 8.20e-02 | 0.212 | 4.26e-03 | |
| CD11c (ITGAX) | -0.013 | 7.95e-01 | 0.025 | 6.21e-01 | -0.109 | 1.38e-01 | 0.006 | 9.36e-01 | |
| Th1 | T-bet (TBX21) | -0.062 | 2.11e-01 | -0.041 | 4.23e-01 | -0.152 | 3.83e-02 | -0.041 | 5.82e-01 |
| STAT4 | -0.046 | 3.45e-01 | -0.024 | 6.44e-01 | -0.125 | 8.90e-02 | 0 | 9.98e-01 | |
| STAT1 | 0.4 | 0.00e+00 | 0.402 | 3.51e-16 | 0.179 | 1.50e-02 | 0.248 | 8.04e-04 | |
| IFN-γ (IFNG) | 0.211 | 1.39e-05 | 0.23 | 6.28e-06 | 0.003 | 9.66e-01 | 0.084 | 2.60e-01 | |
| TNF-α (TNF) | 0.084 | 8.93e-02 | 0.115 | 2.56e-02 | 0.134 | 6.99e-02 | 0.184 | 1.34e-02 | |
| Th2 | GATA3 | -0.189 | 1.11e-04 | -0.166 | 1.14e-03 | 0.006 | 9.40e-01 | 0.075 | 3.16e-01 |
| STAT6 | 0.036 | 4.71e-01 | 0.025 | 6.30e-01 | 0.115 | 1.20e-01 | 0.111 | 1.36e-01 | |
| STAT5A | 0.002 | 9.64e-01 | 0.022 | 6.76e-01 | -0.008 | 9.13e-01 | 0.053 | 4.76e-01 | |
| IL13 | -0.007 | 8.84e-01 | 0.003 | 9.61e-01 | -0.059 | 4.22e-01 | 0.003 | 9.73e-01. | |
| Tfh | BCL6 | -0.197 | 5.36e-05 | -0.186 | 2.71e-04 | 0.19 | 9.51e-03 | 0.189 | 1.11e-02 |
| IL21 | 0.146 | 2.80e-03 | 0.181 | 3.91e-04 | -0.049 | 5.1e-01 | -0.001 | 9.89e-01 | |
| Th17 | STAT3 | 0.075 | 1.28e-01 | 0.077 | 1.33e-01 | 0.196 | 5.73e-03 | 0.234 | 1.54e-03 |
| IL17A | 0.194 | 6.78e-05 | 0.21 | 3.73e-05 | -0.071 | 3.35e-01 | -0.056 | 4.55e-01 | |
| Treg | FOXP3 | 0.067 | 1.75e-01 | 0.095 | 6.41e-02 | 0.024 | 7.48e-01 | 0.115 | 1.24e-01 |
| CCR8 | 0.067 | 1.73e-01 | 0.081 | 1.14e-01 | -0.01 | 8.92e-01 | 0.084 | 2.63e-01 | |
| STAT5B | -0.032 | 5.14e-01 | -0.022 | 6.75e-01 | 0.17 | 2.06e-02 | 0.171 | 2.14e-02 | |
| TGRβ(TGFB1) | -0.161 | 1.02e-03 | -0.142 | 5.45e-03 | 0.105 | 1.54e-01 | 0.156 | 3.63e-02 | |
| T cell exhaustion | PD-1(PDCD1) | 0.007 | 8.86e-01 | 0.036 | 4.81e-01 | -0.013 | 8.61e-01 | -0.101 | 1.7e-01 |
| CTLA4 | 0.182 | 2.02e-04 | 0.219 | 1.72e-05 | 0.075 | 3.15e-01 | -0.028 | 7.06e-01 | |
| LAG3 | 0.071 | 1.47e-01 | 0.086 | 9.52e-02 | 0.077 | 3.04e-01 | -0.008 | 9.11e-01 | |
| TIM-3(HAVCR2) | 0.016 | 7.48e-01 | 0.039 | 4.52e-01 | 0.075 | 3.19e-01 | -0.021 | 7.82e-01 | |
| GZMB | 0.169 | 5.76e-04 | 0.201 | 8.36e-05 | 0.02 | 7.85e-01 | -0.07 | 3.44e-01 | |
STAD, stomach adenocarcinoma; ESCA, esophageal carcinoma; tumor-associated macrophage; Th, T helper cell; Tfh, Follicular helper T cell; Treg, regulatory T cell; Cor, R value of Spearman’s correlation; None, correlation without adjustment. Purity, correlation adjusted by purity. The bold values stands P<0.05.