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. 2023 Jul 6;14:1165574. doi: 10.3389/fendo.2023.1165574

Table 2.

Results of analysis and subgroup analysis.

Outcomes No. studies No. Participants Summary SMD (95%CI) I2 (%)
MSCs controls Random Fixed
E2 30 286 282 2.69 (1.97 to 3.41) 1.38 (1.16 to 1.60) 88
Animal Species
Rats 18 179 174 3.16 (2.16 to 4.16) 1.57 (1.28 to 1.86) 90
Mice 10 97 98 1.55 (0.64 to 2.46) 1.09 (0.75 to 1.43) 83
Mice and Rats 28 276 272 2.53 (1.84 to 3.23) 1.37 (1.14 to 1.59) 88
Rabbits 2 10 10 21.03 (11.10 to 30.97) 20.53 (12.09 to 28.97) 21
Induced
Chemotherapy 26 236 231 2.81 (1.97 to 3.65) 1.34 (1.09 to 1.59) 88
Autoimmune 3 42 43 1.56 (0.67 to 2.46) 1.37 (0.88 to 1.86) 60
Radiation 1 8 8 5.70 (3.23 to 8.18) 5.70 (3.23 to 8.18)
Source of MSCs
Human 18 173 171 2.61 (1.69 to 3.54) 1.32 (1.04 to 1.60) 88
Animal 12 113 111 2.85 (1.63 to 4.08) 1.47 (1.11 to 1.84) 89
Types of MSCs
UCMSCs 13 130 127 2.55 (1.50 to 3.60) 1.25 (0.94 to 1.57) 88
BMMSCs 10 87 87 3.59 (2.33 to 4.84) 2.38 (1.92 to 2.84) 82
AFMSCs 1 8 8 7.55 (4.38 to 10.72) 7.55 (4.38 to 10.72)
CPMSCs 1 6 6 -1.51 (-2.85 to -0.16) -1.51 (-2.85 to -0.16)
MenSCs 2 12 12 4.17 (0.12 to 8.23) 3.14 (1.68 to 4.59) 79
ADMSCs 2 26 24 -0.29 (-2.25 to 1.67) -0.04 (-0.63 to 0.56) 90
PMSCs 1 17 18 1.83 (1.02 to 2.63) 1.83 (1.02 to 2.63)
Dose of transplantation
105 3 15 15 14.82 (0.21 to 29.42) 4.40 (2.25 to 6.55) 88
106 22 231 227 2.59 (1.85 to 3.32) 1.49 (1.25 to 1.73) 87
107 5 40 40 2.34 (0.03 to 4.64) 0.54 (-0.03 to 1.12) 91
Route of transplantation
IV 20 182 183 2.91 (1.91 to 3.91) 1.40 (1.11 to 1.68) 89
IO 10 104 99 2.40 (1.35 to 3.46) 1.35 (1.00 to 1.70) 86
FSH 27 255 253 -2.02 (-2.74 to -1.30) -1.49 (-1.73 to -1.26) 88
Animals
Rats 15 149 146 -2.52 (-3.41 to -1.63) -1.87 (-2.19 to -1.56) 86
Mice 10 96 97 -0.97 (-2.05 to 0.11) -1.00 (-1.35 to -0.65) 88
Mice and Rats 25 245 243 -1.89 (-2.58 to -1.20) -1.48 (-1.72 to -1.24) 87
Rabbits 2 10 10 -21.73 (-30.46 to -13.00) -21.73 (-30.46 to -13.00) 0
Induced
Chemotherapy 23 205 202 -1.66 (-2.37 to -0.94) -1.22 (-1.47 to -0.97) 85
Autoimmune 3 42 43 -3.40 (-5.30 to -1.50) -3.50 (-4.23 to -2.76) 84
Radiation 1 8 8 -5.68 (-8.15 to -3.21) -5.68 (-8.15 to -3.21)
Source of MSCs
Human 15 153 151 -1.61 (-2.74 to -0.47) -1.21 (-1.51 to -0.90) 91
Animal 12 102 102 -2.45 (-3.22 to -1.68) -1.92 (-2.29 to -1.55) 72
Types of MSCs
UCMSCs 12 122 119 -2.07 (-3.27 to -0.88) -1.31 (-1.64 to -0.97) 90
BMMSCs 11 92 92 -2.63 (-3.48 to -1.78) -2.07 (-2.47 to -1.66) 72
AFMSCs 1 8 8 0.70 (-0.32 to 1.72) 0.70 (-0.32 to 1.72)
CPMSCs 1 6 6 4.56 (2.06 to 7.06) 4.56 (2.06 to 7.06)
PMSCs 1 17 18 -3.45 (-4.53 to -2.36) -3.45 (-4.53 to -2.36)
ADMSCs 1 10 10 -1.10 (-2.05 to -0.14) -1.10 (-2.05 to -0.14)
Dose of transplantation
105 6 45 45 -1.45 (-2.88 to -0.01) -1.04 (-1.57 to -0.52) 85
106 18 195 193 -2.07 (-2.91 to -1.23) -1.60 (-1.87 to -1.33) 89
107 3 15 15 -14.22 (-30.74 to 2.30) -1.92 (-3.36 to -0.48) 90
Route of transplantation
IV 17 162 163 -2.11 (-3.05 to -1.17) -1.45 (-1.75 to -1.16) 88
IO 10 93 90 -1.91 (-3.11 to -0.71) -1.57 (-1.96 to -1.18) 88
Primary follicles 13 128 126 2.04 (1.17 to 2.92) 1.71 (1.39 to 2.04) 86
Animals
Rats 7 66 63 1.61 (0.68 to 2.54) 1.45 (1.03 to 1.88) 77
Mice 6 62 63 2.96 (1.18 to 4.74) 2.09 (1.58 to 2.60) 89
Mice and Rats 13 128 126 2.04 (1.17 to 2.92) 1.71 (1.39 to 2.04) 86
Induced
Chemotherapy 9 83 83 1.76 (0.66 to 2.87) 1.35 (0.96 to 1.73) 85
Autoimmune 4 45 43 2.65 (1.55 to 3.74) 2.65 (2.03 to 3.26) 65
Source of MSCs
Human 12 123 121 2.20 (1.28 to 3.12) 1.81 (1.47 to 2.15) 84
Animal 1 5 5 0.37 (-0.89 to 1.62) 0.37 (-0.89 to 1.62)
Types of MSCs
UCMSCs 10 91 88 2.29 (1.11 to 3.47) 1.65 (1.25 to 2.05) 86
BMMSCs 1 5 5 0.37 (-0.89 to 1.62) 0.37 (-0.89 to 1.62)
AFMSCs 2 32 33 2.24 (1.45 to 3.02) 2.23 (1.59 to 2.87) 34
Dose of transplantation
105 2 9 9 2.76 (-0.56 to 6.08) 2.44 (0.91 to 3.98) 77
106 10 104 102 2.01 (0.94 to 3.08) 1.65 (1.29 to 2.01) 87
107 1 15 15 1.85 (0.98 to 2.73) 1.85 (0.98 to 2.73)
Route of transplantation
IV 8 100 101 2.18 (1.01 to 3.34) 1.77 (1.40 to 2.13) 88
IO 5 28 25 1.86 (0.49 to 3.22) 1.51 (0.79 to 2.23) 70
Secondary follicles 12 120 118 1.93 (1.05 to 2.81) 1.56 (1.23 to 1.89) 85
Animals
Rats 6 58 55 1.85 (1.09 to 2.62) 1.85 (1.38 to 2.33) 57
Mice 6 62 63 2.39 (0.70 to 4.09) 1.29 (0.84 to 1.75) 90
Mice and Rats 12 120 118 1.93 (1.05 to 2.81) 1.56 (1.23 to 1.89) 85
Induced
Chemotherapy 8 75 75 3.06 (1.38 to 4.75) 1.83 (1.38 to 2.27) 85
Autoimmune 4 45 43 1.35 (-0.12 to 2.83) 1.24 (0.75 to 1.89) 80
Source of MSCs
Human 11 115 113 2.01 (1.06 to 2.97) 1.58 (1.24 to 1.91) 85
Animal 1 5 5 1.29 (-0.15 to 2.73) 1.29 (-0.15 to 2.73)
Types of MSCs
UCMSCs 9 83 80 2.25 (0.97 to 3.54) 1.49 (1.08 to 1.90) 87
BMMSCs 1 5 5 1.29 (-0.15 to 2.73) 1.29 (-0.15 to 2.73)
PMSCs 2 32 33 1.82 (0.90 to 2.73) 1.76 (1.17 to 2.35) 56
Dose of transplantation
105 2 9 9 4.45 (2.28 to 6.62) 4.45 (2.28 to 6.62) 0
106 9 96 94 1.60 (0.60 to 2.59) 1.38 (1.02 to 1.73) 85
107 1 15 15 2.34 (1.38 to 3.29) 2.34 (1.38 to 3.29)
Route of transplantation
IV 7 92 93 2.21 (1.09 to 3.32) 1.79 (1.41 to 2.17) 87
IO 5 28 25 1.47 (0.03 to 2.91) 0.84 (0.17 to 1.50) 73
Primordial follicles 11 105 102 2.38 (1.19 to 3.57) 1.25 (0.89 to 1.61) 89
Animals
Rats 6 53 50 2.65 (0.79 to 4.51) 1.46 (0.93 to 2.00) 90
Mice 5 52 52 2.22 (0.44 to 4.01) 1.08 (0.59 to 1.56) 91
Mice and Rats 11 105 102 2.38 (1.19 to 3.57) 1.25 (0.89 to 1.61) 89
Induced
Chemotherapy 8 77 77 2.47 (1.04 to 3.89) 1.04 (0.64 to 1.45) 90
Autoimmune 3 28 25 2.19 (-0.27 to 4.66) 2.04 (1.25 to 2.82) 90
Source of MSCs
Human 9 90 87 2.01 (0.83 to 3.18) 1.20 (0.82 to 1.57) 88
Animal 2 15 15 6.09 (-4.54 to 16.72) 1.86 (0.60 to 3.13) 96
Types of MSCs
UCMSCs 9 90 87 2.01 (0.83 to 3.18) 1.20 (0.82 to 1.57) 88
BMMSCs 2 15 15 6.09 (-4.54 to 16.72) 1.86 (0.60 to 3.13) 96
Dose of transplantation
105 2 9 9 2.71 (-2.03 to 7.45) 1.67 (0.24 to 3.09) 88
106 9 96 93 2.36 (1.06 to 3.65) 1.22 (0.85 to 1.59) 91
Route of transplantation
IV 6 77 77 3.12 (1.30 to 4.94) 1.29 (0.87 to 1.71) 93
IO 5 28 25 1.57 (0.08 to 3.05) 1.14 (0.45 to 1.82) 77
AMH 7 65 65 1.41 (0.67 to 2.14) 1.29 (0.89 to 1.70) 67
Animals
Rats 2 10 10 0.81 (-0.14 to 1.75) 0.81 (-0.14 to 1.75) 0
Mice 4 50 50 1.68 (0.54 to 2.81) 1.40 (0.94 to 1.87) 82
Mice and Rats 6 60 60 1.41 (0.58 to 2.24) 1.28 (0.87 to 1.70) 72
Rabbits 1 5 5 1.41 (-0.06 to 2.89) 1.41 (-0.06 to 2.89)
Induced
Chemotherapy 7 65 65 1.41 (0.67 to 2.14) 1.29 (0.89 to 1.70) 67
Source of MSCs
Human 7 65 65 1.41 (0.67 to 2.14) 1.29 (0.89 to 1.70) 67
Types of MSCs
UCMSCs 7 65 65 1.41 (0.67 to 2.14) 1.29 (0.89 to 1.70) 67
Dose of transplantation
105 2 13 13 0.88 (0.06 to 1.71) 0.88 (0.06 to 1.71) 0
106 4 47 47 1.66 (0.46 to 2.86) 1.42 (0.94 to 1.91) 82
107 1 5 5 1.41 (-0.06 to 2.89) 1.41 (-0.06 to 2.89)
Route of transplantation
IV 5 52 52 1.61 (0.62 to 2.60) 1.42 (0.96 to 1.89) 76
IO 2 13 13 0.88 (0.06 to 1.71) 0.88 (0.06 to 1.71) 0
LH 6 68 68 -2.53 (-3.79 to -1.27) -2.04 (-2.50 to -1.58) 85
Animals
Rats 4 51 51 -3.16 (-4.97 to -1.35) -2.50 (-3.08 to -1.92) 89
Mice 2 17 17 -1.24 (-2.01 to -0.48) -1.24 (-2.01 to -0.48) 0
Mice and Rats 6 68 68 -2.53 (-3.79 to -1.27) -2.04 (-2.50 to -1.58) 85
Induced
Chemotherapy 5 48 48 -2.20 (-3.45 to -0.95) -1.64 (-2.15 to -1.12) 81
Autoimmune 1 20 20 -3.81 (-4.88 to -2.73) -3.81 (-4.88 to -2.73)
Source of MSCs
Human 3 42 42 -2.23 (-3.84 to -0.62) -2.07 (-2.64 to -1.49) 87
Animal 3 26 26 -3.08 (-5.82 to -0.33) -1.99 (-2.77 to -1.20) 89
Types of MSCs
UCMSCs 3 42 42 -2.23 (-3.84 to -0.62) -2.07 (-2.64 to -1.49) 87
BMMSCs 2 16 16 -4.21 (-8.90 to 0.47) -3.47 (-4.81 to -2.13) 91
ADMSCs 1 10 10 -1.21 (-2.18 to -0.24) -1.21 (-2.18 to -0.24)
Dose of transplantation
105 3 27 27 -1.23 (-1.83 to -0.63) -1.23 (-1.83 to -0.63) 0
106 3 41 41 -3.90 (-6.10 to -1.70) -3.23 (-3.96 to -2.50) 87
Route of transplantation
IV 4 43 43 -2.32 (-3.84 to -0.80) -1.61 (-2.15 to -1.07) 85
IO 2 25 25 -2.96 (-4.82 to -1.09) -3.23 (-4.13 to -2.33) 73
FSH/LH 3 23 23 -0.08 (-0.66 to 0.49) -0.08 (-0.66 to 0.49) 0
Animals
Rats 1 6 6 -0.06 (-1.20 to 1.07) -0.06 (-1.20 to 1.07)
Mice 1 12 12 -0.10 (-0.90 to 0.71) -0.10 (-0.90 to 0.71)
Mice and Rats 2 18 18 -0.08 (-0.74 to 0.57) -0.08 (-0.74 to 0.57) 0
Rabbits 1 5 5 -0.08 (-1.32 to 1.16) -0.08 (-1.32 to 1.16)
Induced
Chemotherapy 3 23 23 -0.08 (-0.66 to 0.49) -0.08 (-0.66 to 0.49) 0
Source of MSCs
Human 3 23 23 -0.08 (-0.66 to 0.49) -0.08 (-0.66 to 0.49) 0
Types of MSCs
UCMSCs 3 23 23 -0.08 (-0.66 to 0.49) -0.08 (-0.66 to 0.49) 0
Dose of transplantation
106 2 18 18 -0.08 (-0.74 to 0.57) -0.08 (-0.74 to 0.57) 0
107 1 5 5 -0.08 (-1.32 to 1.16) -0.08 (-1.32 to 1.16)
Route of transplantation
IV 3 23 23 -0.08 (-0.66 to 0.49) -0.08 (-0.66 to 0.49) 0
INHB 2 10 10 23.51 (14.11 to 32.91) 23.51 (14.11 to 32.91) 0
Animals
Rats 1 5 5 23.53 (10.23 to 36.84) 23.53 (10.23 to 36.84)
Mice 1 5 5 23.49 (10.21 to 36.77) 23.49 (10.21 to 36.77)
Mice and Rats 2 10 10 23.51 (14.11 to 32.91) 23.51 (14.11 to 32.91) 0
Induced
Chemotherapy 2 10 10 23.51 (14.11 to 32.91) 23.51 (14.11 to 32.91) 0
Source of MSCs
Human 2 10 10 23.51 (14.11 to 32.91) 23.51 (14.11 to 32.91) 0
Types of MSCs
UCMSCs 2 10 10 23.51 (14.11 to 32.91) 23.51 (14.11 to 32.91) 0
Dose of transplantation
106 1 5 5 23.53 (10.23 to 36.84) 23.53 (10.23 to 36.84)
107 1 5 5 23.49 (10.21 to 36.77) 23.49 (10.21 to 36.77)
Route of transplantation
IV 2 10 10 23.51 (14.11 to 32.91) 23.51 (14.11 to 32.91) 0
Atretic follicles 9 92 92 -1.71 (-3.08 to -0.33) -1.69 (-2.09 to -1.28) 90
Animals
Rats 4 41 41 -2.41 (-3.86 to -0.96) -1.76 (-2.33 to -1.20) 81
Mice 4 46 46 -0.25 (-3.32 to 2.82) -1.49 (-2.10 to -0.88) 95
Mice and Rats 8 87 87 -1.57 (-3.06 to -0.09) -1.64 (-2.05 to -1.22) 91
Rabbits 1 5 5 -2.83 (-4.84 to -0.81) -2.83 (-4.84 to -0.81)
Induced
Chemotherapy 9 92 92 -1.71 (-3.08 to -0.33) -1.69 (-2.09 to -1.28) 90
Source of MSCs
Human 8 82 82 -1.27 (-2.62 to 0.07) -1.54 (-1.95 to -1.13) 89
Animal 1 10 10 -6.07 (-8.35 to -3.80) -6.07 (-8.35 to -3.80)
Types of MSCs
UCMSCs 7 67 67 -1.21 (-2.89 to 0.47) -1.68 (-2.16 to -1.19) 91
BMMSCs 1 10 10 -6.07 (-8.35 to -3.80) -6.07 (-8.35 to -3.80)
PMSCs 1 15 15 -1.18 (-1.97 to -0.40) -1.18 (-2.06 to -1.16)
Dose of transplantation
105 1 9 9 8.00 (4.90 to 11.10) 8.00 (4.90 to 11.10)
106 6 63 63 -2.70 (-4.12 to -1.28) -2.06 (-2.56 to -1.57) 87
107 2 20 20 -1.73 (-3.25 to -0.21) -1.40 (-2.13 to -0.67) 55
Route of transplantation
IV 8 83 83 -2.45 (-3.51 to -1.38) -1.86 (-2.26 to -1.45) 83
IO 1 9 9 8.00 (4.90 to 11.10) 8.00 (4.90 to 11.10)
Antral follicles 6 59 54 2.85 (0.58 to 5.11) 1.90 (1.33 to 2.48) 93
Animals
Rats 3 36 31 2.76 (-0.63 to 6.15) 2.06 (1.32 to 2.80) 95
Mice 3 23 23 3.13 (-0.99 to 7.26) 1.65 (0.72 to 2.58) 94
Mice and Rats 6 59 54 2.85 (0.58 to 5.11) 1.90 (1.33 to 2.48) 93
Induced
Chemotherapy 5 54 49 3.64 (1.24 to 6.04) 2.55 (1.91 to 3.19) 91
Autoimmune 1 5 5 -0.90 (-2.24 to 0.44) -0.90 (-2.24 to 0.44)
Source of MSCs
Human 4 38 35 4.03 (0.31 to 7.74) 2.50 (1.65 to 3.35) 94
Animal 2 21 19 1.02 (-2.13 to 4.18) 1.38 (0.59 to 2.18) 93
Types of MSCs
UCMSCs 4 38 35 4.03 (0.31 to 7.74) 2.50 (1.65 to 3.35) 94
BMMSCs 1 5 5 -0.62 (-1.90 to 0.67) -0.62 (-1.90 to 0.67)
ADMSCs 1 16 14 2.61 (1.60 to 3.61) 2.61 (1.60 to 3.61)
Dose of transplantation
105 1 6 6 7.75 (3.80 to 11.70) 7.75 (3.80 to 11.70)
106 5 53 48 2.17 (-0.14 to 4.48) 1.78 (1.19 to 2.36) 93
Route of transplantation
IV 1 12 12 3.59 (2.22 to 4.96) 3.59 (2.22 to 4.96)
IO 5 47 42 2.74 (0.04 to 5.44) 1.54 (0.90 to 2.18) 93
Growing follicles 5 58 58 2.08 (1.19 to 2.98) 1.80 (1.33 to 2.26) 68
Animals
Rats 3 38 38 2.55 (0.95 to 4.16) 1.96 (1.37 to 2.55) 82
Mice 1 15 15 1.43 (0.61 to 2.24) 1.43 (0.61 to 2.24)
Mice and Rats 4 53 53 2.13 (1.08 to 3.18) 1.78 (1.30 to 2.25) 76
Rabbits 1 5 5 2.05 (0.35 to 3.74) 2.05 (0.35 to 3.74)
Induced
Chemotherapy 5 58 58 2.08 (1.19 to 2.98) 1.80 (1.33 to 2.26) 68
Source of MSCs
Human 4 48 48 1.61 (1.13 to 2.08) 1.61 (1.13 to 2.08) 0
Animal 1 10 10 5.29 (3.26 to 7.32) 5.29 (3.26 to 7.32)
Types of MSCs
UCMSCs 4 48 48 1.61 (1.13 to 2.08) 1.61 (1.13 to 2.08) 0
BMMSCs 1 10 10 5.29 (3.26 to 7.32) 5.29 (3.26 to 7.32)
Dose of transplantation
106 4 53 53 2.13 (1.08 to 3.18) 1.78 (1.30 to 2.25) 76
107 1 5 5 2.05 (0.35 to 3.74) 2.05 (0.35 to 3.74)
Route of transplantation
IV 5 58 58 2.08 (1.19 to 2.98) 1.80 (1.33 to 2.26) 68
Mature follicles 5 56 53 3.10 (1.86 to 4.34) 2.62 (2.06 to 3.19) 76
Animals
Rats 5 56 53 3.10 (1.86 to 4.34) 2.62 (2.06 to 3.19) 76
Induced
Chemotherapy 3 33 33 2.69 (1.00 to 4.38) 2.18 (1.51 to 2.85) 81
Autoimmune 2 23 20 3.76 (2.69 to 4.83) 3.76 (2.69 to 4.83) 0
Source of MSCs
Human 4 46 43 2.64 (1.52 to 3.76) 2.40 (1.81 to 2.99) 69
Animal 1 10 10 5.29 (3.26 to 7.32) 5.29 (3.26 to 7.32)
Types of MSCs
UCMSCs 3 31 28 2.97 (1.32 to 4.63) 2.72 (1.93 to 3.50) 75
BMMSCs 1 10 10 5.29 (3.26 to 7.32) 5.29 (3.26 to 7.32)
PMSCs 1 15 15 1.98 (1.09 to 2.88) 1.98 (1.09 to 2.88)
Dose of transplantation
106 4 41 38 3.50 (1.86 to 5.13) 3.05 (2.32 to 3.78) 78
107 1 15 15 1.98 (1.09 to 2.88) 1.98 (1.09 to 2.88)
Route of transplantation
IV 4 47 47 2.90 (1.53 to 4.27) 2.49 (1.90 to 3.08) 79
IO 1 9 6 4.15 (2.14 to 6.16) 4.15 (2.14 to 6.16)
Corpus leteum 5 44 41 1.02 (-1.47 to 3.51) 0.27 (-0.32 to 0.86) 93
Animals
Rats 4 39 36 1.96 (-0.81 to 4.72) 0.56 (-0.06 to 1.17) 94
Rabbits 1 5 5 -2.85 (-4.88 to -0.82) -2.85 (-4.88 to -0.82)
Induced
Chemotherapy 3 21 21 -1.18 (-2.15 to -0.21) -1.05 (-1.73 to -0.36) 42
Autoimmune 2 23 20 5.19 (0.99 to 9.39) 3.81 (2.68 to 4.93) 82
Source of MSCs
Human 5 44 41 1.02 (-1.47 to 3.51) 0.27 (-0.32 to 0.86) 93
Types of MSCs
UCMSCs 5 44 41 1.02 (-1.47 to 3.51) 0.27 (-0.32 to 0.86) 93
Dose of transplantation
106 4 39 36 1.96 (-0.81 to 4.72) 0.56 (-0.06 to 1.17) 94
107 1 5 5 -2.85 (-4.88 to -0.82) -2.85 (-4.88 to -0.82)
Route of transplantation
IV 4 35 35 -0.22 (-2.56 to 2.11) 0.04 (-0.56 to 0.63) 93
IO 1 9 6 7.65 (4.30 to 11.00) 7.65 (4.30 to 11.00)
Follicles 3 30 30 3.05 (-0.58 to 6.69) 2.51 (1.66 to 3.37) 94
Animals
Rats 3 30 30 3.05 (-0.58 to 6.69) 2.51 (1.66 to 3.37) 94
Induced
Chemotherapy 2 10 10 1.06 (0.08 to 2.05) 1.06 (0.08 to 2.05) 0
Autoimmune 1 20 20 7.03 (5.30 to 8.77) 7.03 (5.30 to 8.77)
Source of MSCs
Human 1 20 20 7.03 (5.30 to 8.77) 7.03 (5.30 to 8.77)
Animal 2 10 10 1.06 (0.08 to 2.05) 1.06 (0.08 to 2.05) 0
Types of MSCs
UCMSCs 1 20 20 7.03 (5.30 to 8.77) 7.03 (5.30 to 8.77)
BMMSCs 2 10 10 1.06 (0.08 to 2.05) 1.06 (0.08 to 2.05) 0
Dose of transplantation
106 2 25 25 3.85 (-2.33 to 10.03) 3.00 (1.95 to 4.04) 97
107 1 5 5 1.51 (0.01 to 3.01) 1.51 (0.01 to 3.01)
Route of transplantation
IO 3 30 30 3.05 (-0.58 to 6.69) 2.51 (1.66 to 3.37) 94
Early antral 2 15 15 1.00 (0.23 to 1.78) 1.00 (0.23 to 1.78) 0
Animals
Rats 2 15 15 1.00 (0.23 to 1.78) 1.00 (0.23 to 1.78) 0
Induced
Chemotherapy 2 15 15 1.00 (0.23 to 1.78) 1.00 (0.23 to 1.78) 0
Source of MSCs
Human 2 15 15 1.00 (0.23 to 1.78) 1.00 (0.23 to 1.78) 0
Types of MSCs
UCMSCs 2 15 15 1.00 (0.23 to 1.78) 1.00 (0.23 to 1.78) 0
Dose of transplantation
105 1 3 3 0.65 (-1.07 to 2.37) 0.65 (-1.07 to 2.37)
106 1 12 12 1.09 (0.22 to 1.96) 1.09 (0.22 to 1.96)
Route of transplantation
IV 1 12 12 1.09 (0.22 to 1.96) 1.09 (0.22 to 1.96)
IO 1 3 3 0.65 (-1.07 to 2.37) 0.65 (-1.07 to 2.37)
Estruc cycle 7 90 90 0.00 (-1.65 to 1.66) 0.54 (0.17 to 0.91) 94
Animals
Rats 4 70 70 0.59 (-1.57 to 2.75) 0.88 (0.46 to 1.29) 96
Mice 3 20 20 -0.85 (-3.63 to 1.93) -0.78 (-1.60 to 0.05) 90
Mice and Rats 7 90 90 0.00 (-1.65 to 1.66) 0.54 (0.17 to 0.91) 94
Induced
Chemotherapy 5 40 40 -0.62 (-2.68 to 1.44) -0.17 (-0.75 to 0.40) 92
Autoimmune 1 20 20 -0.31 (-0.93 to 0.31) -0.31 (-0.93 to 0.31)
Radiation 1 30 30 3.18 (2.40 to 3.96) 3.18 (2.40 to 3.96)
Source of MSCs
Human 6 60 60 -0.54 (-1.98 to 0.90) -0.24 (-0.66 to 0.19) 90
Animal 1 30 30 3.18 (2.40 to 3.96) 3.18 (2.40 to 3.96)
Types of MSCs
UCMSCs 4 46 46 -0.66 (-2.32 to 1.00) -0.20 (-0.67 to 0.26) 90
BMMSCs 1 30 30 3.18 (2.40 to 3.96) 3.18 (2.40 to 3.96)
AFMSCs 1 8 8 -2.46 (-3.84 to -1.07) -2.46 (-3.84 to -1.07)
CPMSCs 1 6 6 2.01 (0.51 to 3.51) 2.01 (0.51 to 3.51)
Dose of transplantation
105 1 6 6 -3.07 (-4.95 to -1.19) -3.07 (-4.95 to -1.19)
106 6 84 84 0.46 (-1.24 to 2.16) 0.69 (0.31 to 1.07) 95
Route of transplantation
IV 5 64 64 0.61 (-1.54 to 2.76) 1.27 (0.79 to 1.75) 95
IO 2 26 26 -1.54 (-4.23 to 1.15) -0.58 (-1.18 to -0.01) 87

UC-MSCs, umbilical cord mesenchymal stem cells; BMMSCs, bone marrow mesenchymal stem cells; MenSCs, Menstrual blood mesenchymal stem cells; PMSCs, placenta mesenchymal stem cells; CPMSCs, chorionic plate mesenchymal stem cells; ADMSCs, adipose mesenchymal stem cell; AFMSCs, amniotic fluid mesenchymal stem cells; IV, intravenously injected; IO, intra ovary injected; LH, luteinizing hormone; FSH, follicle-stimulating hormone; E2, estradiol; AMH, anti Mullerian hormone; INHB, inhibin B; SMD, standardized mean difference.