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. 2023 Jul 7;14:1180402. doi: 10.3389/fimmu.2023.1180402

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Copyright © 2023 Huang, Bu, Yang, Huang, Zhang, Li and Ding

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Isg15 ⁺ macrophages correlate with lung metastasis of breast cancer. (A) UMAP clustering of macrophages in different tissues and lung metastasis stages. (B) The histogram comparing the percent of macrophage clusters in different tissues. (C) The heatmap displaying the percent of macrophage clusters in different lung metastasis stages. (D) Hierarchical clustering of macrophage clusters. (E) The dot plot of Isg15 and Prg4 across macrophage clusters. (F) The volcano plots of differential gene expression of Isg15 ⁺ and Prg4 ⁺ macrophages. (G) The enrichment analysis of GO biological process in Isg15 ⁺ and Prg4 ⁺ macrophages. (H) The heatmap displaying the differential expression of genes in macrophage clusters. (I) The schematic diagram displaying characteristics of Prg4 ⁺ macrophage in normal lung and Isg15 ⁺ macrophage in breast cancer lung metastasis.