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. 2023 Jul 7;14:1180402. doi: 10.3389/fimmu.2023.1180402

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Copyright © 2023 Huang, Bu, Yang, Huang, Zhang, Li and Ding

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Ifit3 ⁺ neutrophils correlate with lung metastasis of breast cancer. (A) UMAP clustering of neutrophils in different tissues and lung metastasis stages. (B) The histogram comparing the percent of neutrophil clusters in different tissues. (C) The heatmap displaying the percent of neutrophil clusters in different lung metastasis stages. (D) Hierarchical clustering of neutrophil clusters. (E) The dot plot of Ifit3 and Cd14 across neutrophil clusters. (F) The volcano plots of differential gene expression of Ifit3 ⁺ and Cd14 ⁺ neutrophils. (G) The enrichment analysis of GO biological process in Ifit3 ⁺ and Cd14 ⁺ neutrophils. (H) The heatmap displaying the differential expression of genes in neutrophil clusters. (I) The schematic diagram displaying characteristics of Cd14 ⁺ neutrophil in normal lung and Ifit3 ⁺ neutrophil in breast cancer lung metastasis.