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. 2023 Jul 7;14:1180402. doi: 10.3389/fimmu.2023.1180402

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Copyright © 2023 Huang, Bu, Yang, Huang, Zhang, Li and Ding

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Il12b ⁺ DCs correlate with lung metastasis of breast cancer. (A) UMAP clustering of DCs in different tissues and lung metastasis stages. (B) The histogram comparing the percent of DC clusters in different tissues. (C) The heatmap displaying the percent of DC clusters in different lung metastasis stages. (D) Hierarchical clustering of DC clusters. (E) The dot plot of Il12b and Vim across DC clusters. (F) The volcano plots of differential gene expression of Il12b ⁺ and Vim ⁺ DCs. (G) The enrichment analysis of GO biological process in Il12b ⁺ and Vim ⁺ DCs. (H) The heatmap displaying the differential expression of genes in DC clusters. (I) The schematic diagram displaying characteristics of Vim ⁺ DC in normal lung and Il12b ⁺ DC in breast cancer lung metastasis.