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. Author manuscript; available in PMC: 2023 Jul 22.
Published in final edited form as: Prog Retin Eye Res. 2021 Dec 29;89:101037. doi: 10.1016/j.preteyeres.2021.101037

Figure 2. Rod OS disks have regionally distinct microenvironments.

Figure 2.

The central region of rod OS disks, rich in rhodopsin (red, PDB: 1F88), has an abundance of long and unsaturated FAs. Rim regions of rod OS disks containing ABCA4 (blue, PDB: 7LKP) and PRPH2/ROM1 (tetramer of human tetraspanin CD81 used as a model in green, PDB: 5TCX) have relatively high amounts of short and saturated FAs. There are many other distinctions in lipid species between the two regions, including relative amounts of PC and PE. ©2021 Sander et al. Adapted from an article originally published in the Journal of Cell Biology. https://doi.org/10.1083/jcb.202101063