Table 3.
Surgical, pathological, and adjuvant treatment details of patients ≥ 75 years who received surgery with or without neoadjuvant chemotherapy
| Neoadjuvant chemotherapy age ≥ 75 (N = 232) | No neoadjuvant chemotherapy age ≥ 75 (N = 471) | P-value | |
|---|---|---|---|
| Interval between onset of neoadjuvant therapy and surgery (days), median (IQR) | 93 (83–105) | – | |
| Non-curable disease during intended gastrectomy no./total no. (%) | 10 (4.3%) | – | |
| Resection performed | N = 222 | N = 471 | |
| Resection type, no./total no. (%) | < 0.001 | ||
| Total gastrectomy | 89 (40.1) | 125 (26.5) | |
| Subtotal gastrectomy | 117 (52.7) | 331 (70.3) | |
| Esophagectomy | 16 (7.2) | 15 (3.2) | |
| Pathological response to neoadjuvant therapy, no./total no. (%) | |||
| Complete | 18 (8.1) | – | |
| Subtotal | 21 (9.5) | – | |
| Partial | 81 (36.5) | – | |
| None | 60 (27.0) | – | |
| Unknown | 42 (18.9) | – | |
| (y)pT-stage, no./total no. (%) | < 0.001 | ||
| T0 | 20 (9.0) | 0 (0.0) | |
| T1 | 22 (9.9) | 94 (20.0) | |
| T2 | 41 (18.5) | 56 (11.9) | |
| T3 | 91 (41.0) | 186 (39.5) | |
| T4 | 48 (21.6) | 132 (28.0) | |
| Tx | 0 (0.0) | 3 (0.6) | |
| (y)pN-stage, no./total no. (%) | 0.062 | ||
| N0 | 96 (43.2) | 175 (37.2) | |
| N1 | 54 (24.3) | 92 (19.5) | |
| N2 | 34 (15.3) | 82 (17.4) | |
| N3 | 37 (16.7) | 114 (24.2) | |
| Nx | 1 (0.5) | 8 (1.7) | |
| Resection margin, no./total no. (%) | 0.098 | ||
| R0 | 183 (82.4) | 388 (82.4) | |
| R1 | 18 (8.1) | 52 (11.0) | |
| R2 | 0 (0.0) | 9 (1.9) | |
| Unknown | 21 (9.5) | 22 (4.7) | |
| 30-day postoperative complications, no./total no. (%) | 0.194 | ||
| Yes | 62 (27.9) | 164 (34.8) | |
| Unknown | 38 (17.10) | 71 (15.1) | |
| Type of complications, no./total no. (%) | 0.091 | ||
| Pulmonary | 17 (7.7) | 20 (4.2) | |
| Cardiac | 2 (0.9) | 13 (2.8) | |
| Trombo-embolic | 3 (1.4) | 4 (0.8) | |
| Anastomotic leakage | 6 (2.7) | 15 (3.2) | |
| Chyle leakage | 3 (1.4) | 3 (0.6) | |
| Wound infection | 12 (5.4) | 30 (6.4) | |
| Neurological | 4 (1.8) | 10 (2.1) | |
| Multiple | 15 (6.8) | 69 (14.6) | |
| Length of hospital stay (days), median (IQR) | 8 (6–11) | 8 (6–14) | 0.097 |
| 30-day postoperative mortality no. (%) | 7 (3.2) | 39 (8.3) | 0.011 |
| Adjuvant therapy no./total no. (%) | < 0.001 | ||
| Yes | 88 (39.6) | 5 (1.1) | |
| Type of adjuvant therapy no./total no. (%) | < 0.001 | ||
| Chemotherapy | 84 (95.5) | 0 (0.0) | |
| Chemoradiotherapy | 4 (4.5) | 5 (100.0) |
IQR, interquartile range