Table 7.

Parameter estimates for different log-normal AFT models with proportion of S100A8 + tumor epithelial cells as the main covariate, unadjusted and adjusted for age, grade, histologic subtype, molecular subtype and Ki67 status

	Proportion of S100A8 + tumor cells
	< 1%	≥ 1%, < 10%	≥ 10%
TR unadjusted (95% CI)	Reference	0.71 (0.37–1.36)	0.20 (0.10–0.42)
TR adjusted for age (95% CI)	Reference	0.78 (0.43–1.39)	0.23 (0.12–0.43)
TR adjusted for grade (95% CI)	Reference	0.91 (0.47–1.77)	0.30 (0.14–0.61)
TR adjusted for histological subtype (95% CI)	Reference	0.66 (0.34–1.27)	0.20 (0.10–0.41)
TR adjusted for molecular subtype (95% CI)	Reference	1.05 (0.54–2.05)	0.39 (0.18–0.86)
TR adjusted for Ki67 status (95% CI)	Reference	0.78 (0.41–1.49)	0.25 (0.12–0.51)

TR time ratio, CI confidence interval