Fig. 1.

Treatment with docetaxel induces necrosis in MC38 tumors. (A) Graphical representation of experimental design. Representative H&E stains showing necrotic areas (outlined in black) in MC38 tumors harvested from (B) untreated animals or (C) animals treated with docetaxel on day 17 post-tumor inoculation. (D) Percentage necrosis was quantified by a blinded board-certified pathologist. Quantification of percent necrosis in tumors from animals treated with 500 µg (n = 4) and 1500 µg (n = 4) docetaxel and untreated controls (n = 5). SOC = standard of care. *p < 0.05, **p < 0.01