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. 2023 Apr 16;72(8):2623–2633. doi: 10.1007/s00262-023-03437-z

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — B7-H3 expression on human OS cell lines. A Diagram that shows the second-generation fully human anti-FITC CAR construct domains. B Schematic representation of our model using a switchable CAR T cell strategy based on an anti-B7-H3 mAb conjugated with FITC and anti-FITC CAR T cells. C B7-H3 expression is determined on different OS human cell lines by flow cytometry. Soft gray: negative control, dark gray: anti-B7-H3 stained