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. 2023 May 30;26(5):653–666. doi: 10.1007/s10120-023-01395-0

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Genome-wide transcriptome regulation of CDH1 CNV and CDH1-TANGO6 CNV. A) Volcano-plot illustrating CDH1 CNV differentially expressed genes with CDH1 WT; B Volcano-plot illustrating CDH1-TANGO6 CNV differentially expressed genes with CDH1 WT; C Volcano-plot illustrating CDH1-TANGO6 CNV differentially expressed genes with CDH1 CNV; D Heatmap illustrating genome-wide differentially expressed genes; E Selected genome-wide transcriptomic misregulated pathways of CDH1-TANGO6 CNV and CDH1 CNV. Grey scale represents q value and red–green scale represents z-score (red for pathways with mainly downregulated genes, white for equally downregulated and upregulated genes and green for pathways with mainly upregulated genes); F Response to interferon, TGF-β and Wnt signalling pathways misregulated in CDH1-TANGO6 CNV vs CDH1 CNV, created with BioRender.com. Red–green scale represents down- to upregulated genes and blue represents normal expressed genes