. 2023 May 10;72(8):2757–2768. doi: 10.1007/s00262-023-03458-8

Table 3.

Diagnostic performance of multi-panel biomarkers and CA19-9 for pancreatic adenocarcinoma in suspicious PDAC group

Marker	Sensitivity (95% CI)	Specificity (95% CI)	Accuracy (95% CI)	PPV (95% CI)	NPV (95% CI)	Modified FNR^† (95% CI)	AUC (95% CI)	p-value^‡
CT	NA	NA	NA	NA	70.8 (62.4–79.2)	29.2 (20.8–37.6)	NA	< 0.0001
CA19-9	63.6 (47.2–80.0)	77.5 (68.3–86.7)	73.5 (65.3–81.6)	53.8 (38.2–69.5)	83.8 (75.4–92.2)	10.6 (4.9–16.3)	70.6 (61.0–80.1)	0.4039
Biomarkers panel	72.7 (57.5–87.9)	78.8 (69.8–87.7)	77.0 (69.2–84.8)	58.5 (43.5–73.6)	87.5 (79.9–95.1)	8.0 (3.0–13.0)	75.7 (66.8–84.7)	Reference

Marker

Sensitivity
(95% CI)

Specificity
(95% CI)

Accuracy
(95% CI)

PPV
(95% CI)

NPV
(95% CI)

Modified FNR^†
(95% CI)

AUC
(95% CI)

p-value^‡

70.8

(62.4–79.2)

29.2

(20.8–37.6)

< 0.0001

CA19-9

63.6

(47.2–80.0)

77.5

(68.3–86.7)

73.5

(65.3–81.6)

53.8

(38.2–69.5)

83.8

(75.4–92.2)

10.6

(4.9–16.3)

70.6

(61.0–80.1)

0.4039

Biomarkers panel

72.7

(57.5–87.9)

78.8

(69.8–87.7)

77.0

(69.2–84.8)

58.5

(43.5–73.6)

87.5

(79.9–95.1)

8.0

(3.0–13.0)

75.7

(66.8–84.7)

Reference

Values are % (95% confidence interval)

Cut-off points: CA19-9 > 37.0, Biomarkers panel > 0.22016

PPV, positive predictive value; NPV, negative predictive value; FNR, False negative rate; AUC, area under curve; CA19-9, carbohydrate antigen 19–9; CT, computed tomography; NA, non-available

^†, Modified FNR calculated False Negative/Total N

^‡, p−value compared with biomarkers panel for FNR