Table 1.

The primary outcome sum pain intensity over 6 h (SPI), SPI for each sex, baseline pain at drug intake, number needed to treat (NNT), number needed to prevent rescue drug intake (NNTp), and rescue drug details for each trial group are shown. Present pain was scored on numerical rating scales (0–10 NRS) ranging from

	Paracetamol 1000 mg Ibuprofen 400 mg	Paracetamol 1000 mg Codeine 60 mg	Paracetamol 1000 mg Ibuprofen 400 mg Codeine 60 mg	Placebo
	n = 50	n = 50	n = 50	n = 50
	F/M = 25/25	F/M = 28/22	F/M = 29/21	F/M = 26/24
Pain at drug intake (NRS)
Median	6.0	5.0	5.5	5.0
(Q1, Q3)	(4.8, 7.0)	(4.0, 6.0)	(4.0, 6.3)	(4.0, 6.3)
Median (females)	6.0	5.5	6.0	6.0
(Q1, Q3)	(5.0, 7.0)	(4.3, 7.0)	(5.0, 7.0)	(4.8, 7.0)
Median (males)	6.0	5.0	5.0	5.0
(Q1, Q3)	(4.0, 7.0)	(4.0, 6.0)	(4.0, 6.0)	(4.0, 6.0)
Mean	6.0	5.5	5.5	5.5
(95% CI)	(5.6, 6.4)	(5.1, 5.9)	(5.1, 5.9)	(5.1, 5.9)
Mean (females)	6.2	5.8	5.8	5.7
(95% CI)	(5.6, 6.8)	(5.2, 6.4)	(5.3, 6.3)	(5.2, 6.3)
Mean (males)	5.7	5.2	5.2	5.3
(95% CI)	(5.2, 6.3)	(4.7, 5.7)	(4.6, 5.8)	(4.8, 5.7)
Primary variable
Sum pain intensity (SPI)
Median	44.5	62.5	39.5	89.0
(Q1, Q3)	(30.8, 56.5)	(40.0, 84.3)	(26.8, 56.3)	(75.0, 116.3)
Mean	47.6	65.2	43.5	94.3
(95% CI)	(42.2, 53.0)	(56.0, 74.4)	(37.7, 49.3)	(87.7, 100.9)
Median (females)	44.0	71.5	49.0	90.0
(Q1, Q3)	(33.5, 55.0)	(53.5, 92.5)	(33.0, 66.0)	(80.3, 119.3)
Mean (females)	46.2	73.3	50.7	95.7
(95% CI)	(39.5, 53.0)	(61.1, 85.5)	(42.7, 58.7)	(86.0, 105.4)
Median (males)	47.0	43.0	29.0	89.0
(Q1, Q3)	(28.0, 60.5)	(33.8, 69.3)	(26.0, 39.5)	(74.3, 115.8)
Mean (males)	48.9	54.8	33.6	92.8
(95% CI)	(40.1, 57.8)	(41.0, 68.6)	(26.6, 40.6)	(83.2, 102.3)
Secondary variables
NNT	1.8	2.6	1.7	n/a
NNTp	1.5	5.0	1.7	n/a
Rescue drug intake
Patients/no tablets	4/6	28/51	8/12	38/85