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. 2023 Jul 21;80(8):220. doi: 10.1007/s00018-023-04852-2

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Alternative strategies to target hypoxic tumors. Schematic representation of additional strategies under implementation to target hypoxic tumors. LNPs, lipid nanoparticles encapsulating plasmids for the expression of suicide genes or CRISPR-Cas9 under the control of the VEGF promoter (5xHRE). HAPs, hypoxia activated prodrugs. The figure was created with Biorender.com