Table 2.
Differences in mitochondrial allelic frequencies among patients with BD, patients with SZ, and HCs
| MAF (A1) | PSYs | BD | SZ | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Rs number | BP | A1/A2 | PSYs | BD | SZ | HCs | OR | Puncorr (χ2) | P GC | OR | Puncorr (χ2) | P GC | OR | Puncorr (χ2) | P GC |
| rs28625645 | 489 | A/G | 0.32 | 0.33 | 0.31 | 0.37 | 0.79 | 0.26 (1.3) | 0.42 | 0.85 | 0.62 (0.2) | 0.69 | 0.78 | 0.25 (1.3) | 0.47 |
| rs3901846 | 499 | A/G | 0.022 | 0.039 | 0.017 | 0.051 | 0.43 | 0.12 (2.4) | 0.26 | 0.76 | 0.73 (0.1) | 0.78 | 0.33 | 0.083 (3.0) | 0.27 |
| rs3888511 | 961 | G/A | 0.050 | 0.020 | 0.058 | 0.051 | 0.97 | 0.95 (< 0.1) | 0.97 | 0.38 | 0.35 (0.9) | 0.44 | 1.15 | 0.75 (0.1) | 0.84 |
| rs111033179 | 1005 | G/A | - | 0.039 | - | 0.005 | - | - | - | 8.00 | 0.047 (4.0) | 0.10 | - | - | - |
| rs2000974 | 1048 | A/G | 0.018 | - | 0.023 | 0.005 | 3.56 | 0.23 (1.5) | 0.39 | - | - | - | 4.64 | 0.13 (2.3) | 0.34 |
| rs111033358 | 1382 | C/A | 0.081 | 0.059 | 0.087 | 0.10 | 0.78 | 0.46 (0.6) | 0.59 | 0.55 | 0.35 (0.9) | 0.44 | 0.85 | 0.64 (0.2) | 0.77 |
| rs28358573 | 1442 | A/G | 0.022 | 0.020 | 0.023 | 0.025 | 0.88 | 0.84 (< 0.1) | 0.89 | 0.77 | 0.81 (0.1) | 0.84 | 0.91 | 0.90 (< 0.1) | 0.93 |
| rs200251800 | 1709 | A/G | 0.009 | 0 | 0.012 | 0.025 | 0.35 | 0.19 (1.7) | 0.35 | 0 | 0.25 (1.3) | 0.35 | 0.45 | 0.33 (0.9) | 0.54 |
| rs28358580 | 2416 | G/A | - | 0.020 | - | 0.010 | - | - | - | 1.95 | 0.58 (0.3) | 0.65 | - | - | - |
| rs200221487 | 2772 | A/G | 0.090 | 0.020 | 0.11 | 0.066 | 1.39 | 0.37 (0.8) | 0.52 | 0.28 | 0.20 (1.6) | 0.29 | 1.76 | 0.13 (2.3) | 0.33 |
| rs199713564 | 2831 | A/G | 0.014 | 0.020 | 0.012 | 0.051 | 0.26 | 0.029 (4.8) | 0.12 | 0.38 | 0.34 (0.9) | 0.44 | 0.22 | 0.035 (4.4) | 0.18 |
| rs3928306 | 3010 | A/G | 0.39 | 0.37 | 0.40 | 0.32 | 1.36 | 0.14 (2.2) | 0.29 | 1.23 | 0.52 (0.4) | 0.60 | 1.39 | 0.13 (2.3) | 0.33 |
| rs200999343 | 3206 | A/G | 0.11 | 0.12 | 0.10 | 0.051 | 2.26 | 0.033 (4.5) | 0.13 | 2.49 | 0.083 (3.0) | 0.15 | 2.19 | 0.051 (3.8) | 0.21 |
| rs2853516 | 3316 | A/G | 0.014 | 0.020 | 0.012 | 0.010 | 1.34 | 0.75 (0.1) | 0.82 | 1.95 | 0.58 (0.3) | 0.65 | 1.15 | 0.89 (< 0.1) | 0.93 |
| rs41460449 | 3394 | G/A | 0.023 | 0.039 | 0.018 | 0.021 | 1.10 | 0.88 (< 0.1) | 0.92 | 1.92 | 0.45 (0.6) | 0.54 | 0.86 | 0.84 (< 0.1) | 0.90 |
| rs201212638 | 3398 | G/A | 0.018 | - | - | 0 | - | 0.058 (3.6) | 0.17 | - | - | - | - | - | - |
| rs200319905 | 3497 | A/G | 0.046 | 0.040 | 0.047 | 0.041 | 1.13 | 0.80 (0.1) | 0.86 | 0.98 | 0.98 (< 0.1) | 0.99 | 1.17 | 0.75 (0.1) | 0.84 |
| rs3021088 | 5460 | A/G | 0.045 | 0.059 | 0.041 | 0.071 | 0.62 | 0.25 (1.3) | 0.41 | 0.82 | 0.76 (0.1) | 0.80 | 0.56 | 0.21 (1.5) | 0.43 |
| rs200165736 | 6253 | G/A | 0.022 | 0.039 | 0.017 | 0.005 | 4.50 | 0.13 (2.2) | 0.28 | 8.00 | 0.047 (4.0) | 0.10 | 3.48 | 0.25 (1.3) | 0.47 |
| rs28358884 | 8414 | A/G | 0.39 | 0.37 | 0.40 | 0.32 | 1.36 | 0.13 (2.3) | 0.28 | 1.26 | 0.48 (0.5) | 0.56 | 1.39 | 0.13 (2.3) | 0.33 |
| rs201336180 | 8684 | A/G | 0.009 | 0.020 | - | 0.010 | 0.88 | 0.90 (< 0.1) | 0.93 | 1.95 | 0.58 (0.3) | 0.65 | - | - | - |
| rs2000975 | 8701 | A/G | 0.34 | 0.37 | 0.33 | 0.40 | 0.76 | 0.18 (1.8) | 0.34 | 0.89 | 0.71 (0.1) | 0.76 | 0.73 | 0.14 (2.1) | 0.35 |
| rs199646902 | 9053 | A/G | 0.009 | 0 | 0.012 | 0.015 | 0.59 | 0.56 (0.3) | 0.68 | 0 | 0.38 (0.8) | 0.47 | 0.77 | 0.78 (0.1) | 0.86 |
| rs201397417 | 10,345 | G/A | 0.036 | 0.059 | 0.029 | 0.061 | 0.57 | 0.23 (1.4) | 0.39 | 0.96 | 0.96 (< 0.1) | 0.96 | 0.46 | 0.15 (2.1) | 0.35 |
| rs2853826 | 10,398 | A/G | 0.29 | 0.30 | 0.29 | 0.32 | 0.90 | 0.61 (0.3) | 0.71 | 0.92 | 0.81 (0.1) | 0.84 | 0.89 | 0.61 (0.3) | 0.74 |
| rs200478835 | 10,410 | G/A | 0.099 | 0.12 | 0.093 | 0.030 | 3.48 | 5.17 × 10 − 3 (7.8) | 0.045 | 4.24 | 9.70 × 10 − 3 (6.7) | 0.034 | 3.27 | 0.011 (6.4) | 0.11 |
| rs200487531 | 10,609 | G/A | 0.040 | 0.039 | 0.041 | 0.051 | 0.79 | 0.61 (0.3) | 0.71 | 0.76 | 0.73 (0.1) | 0.78 | 0.79 | 0.65 (0.2) | 0.77 |
| rs200873900 | 11,696 | A/G | 0.013 | 0 | 0.017 | 0.025 | 0.52 | 0.37 (0.8) | 0.52 | 0 | 0.25 (1.3) | 0.35 | 0.68 | 0.60 (0.3) | 0.74 |
| rs28359169 | 11,969 | A/G | 0.013 | - | - | 0.005 | 2.67 | 0.38 (0.8) | 0.53 | - | - | - | - | - | - |
| rs2853501 | 13,105 | G/A | 0.014 | 0.020 | 0.012 | 0.036 | 0.37 | 0.14 (2.2) | 0.29 | 0.54 | 0.56 (0.3) | 0.63 | 0.32 | 0.14 (2.2) | 0.34 |
| rs200044200 | 13,135 | A/G | - | 0.059 | - | 0 | - | - | - | - | 6.15 × 10 − 4 (11.7) | 4.9 × 10 − 3 | - | - | - |
| rs28359178 | 13,708 | A/G | 0.036 | 0.078 | 0.023 | 0.005 | 7.29 | 0.030 (4.7) | 0.12 | 16.68 | 8.94 × 10 − 4 (11.0) | 6.4 × 10 − 3 | 4.67 | 0.13 (2.3) | 0.34 |
| rs200657506 | 13,942 | G/A | 0.013 | 0.039 | 0.006 | 0.015 | 0.88 | 0.88 (< 0.1) | 0.91 | 2.64 | 0.28 (1.2) | 0.37 | 0.38 | 0.38 (0.8) | 0.58 |
| rs28357671 | 14,178 | G/A | 0.004 | 0 | 0.006 | 0.020 | 0.22 | 0.14 (2.2) | 0.28 | 0 | 0.30 (1.1) | 0.40 | 0.28 | 0.23 (1.4) | 0.44 |
| rs201551481 | 14,927 | G/A | 0.018 | 0.020 | 0.017 | 0.015 | 1.18 | 0.83 (< 0.1) | 0.88 | 1.29 | 0.82 (< 0.1) | 0.86 | 1.15 | 0.87 (< 0.1) | 0.91 |
| rs200786872 | 14,979 | G/A | 0.11 | 0.12 | 0.10 | 0.051 | 2.26 | 0.033 (4.5) | 0.13 | 2.49 | 0.083 (3.0) | 0.15 | 2.19 | 0.051 (3.8) | 0.21 |
| rs2853506 | 15,218 | G/A | 0.014 | 0 | 0.018 | 0.016 | 0.87 | 0.87 (< 0.1) | 0.90 | 0 | 0.37 (0.8) | 0.47 | 1.13 | 0.88 (< 0.1) | 0.92 |
| rs201250154 | 15,236 | G/A | 0.013 | 0.020 | 0.012 | 0.051 | 0.25 | 0.027 (4.9) | 0.11 | 0.37 | 0.33 (0.9) | 0.43 | 0.22 | 0.034 (4.5) | 0.18 |
| rs527236176 | 15,314 | A/G | 0.022 | 0.039 | - | 0.010 | 2.24 | 0.33 (1) | 0.48 | 3.98 | 0.14 (2.2) | 0.23 | - | - | - |
| rs527236177 | 15,323 | A/G | 0.036 | 0.039 | 0.035 | 0.046 | 0.78 | 0.61 (0.3) | 0.71 | 0.85 | 0.84 (< 0.1) | 0.87 | 0.76 | 0.60 (0.3) | 0.74 |
| rs199951903 | 15,497 | A/G | 0.041 | 0.039 | 0.041 | 0.046 | 0.88 | 0.79 (0.1) | 0.85 | 0.85 | 0.84 (< 0.1) | 0.87 | 0.89 | 0.82 (0.1) | 0.88 |
| rs527236193 | 15,758 | G/A | 0.009 | 0 | 0.012 | 0.015 | 0.59 | 0.56 (0.3) | 0.67 | 0 | 0.38 (0.8) | 0.47 | 0.76 | 0.77 (0.1) | 0.85 |
| rs201023973 | 15,860 | G/A | 0.036 | 0.039 | 0.035 | 0.041 | 0.88 | 0.8 (0.1) | 0.86 | 0.96 | 0.96 (< 0.1) | 0.97 | 0.85 | 0.77 (0.1) | 0.85 |
| rs193303003 | 15,941 | G/A | 0.018 | 0.020 | 0.017 | 0.020 | 0.88 | 0.86 (< 0.1) | 0.90 | 0.97 | 0.97 (< 0.1) | 0.98 | 0.86 | 0.84 (< 0.1) | 0.90 |
| rs41378955 | 16,390 | A/G | 0.040 | 0.059 | 0.035 | 0.015 | 2.72 | 0.12 (2.4) | 0.27 | 4.04 | 0.071 (3.3) | 0.14 | 2.34 | 0.22 (1.5) | 0.44 |
MAF, minor allele frequency; BP, biological position; OR, odds ratio; PSY, psychotic disorder; BD, bipolar disorder; SZ, schizophrenia
The reference genome sequence is GRCh38/hg38. Puncorr values < 0.05 are shown in boldface. PGC values < 0.05 are shown in boldface and underlined