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. 2023 Jul 21;14(7):459. doi: 10.1038/s41419-023-05985-9

Fig. 7. NDRG1 enhancing the motility of NPC cells in vitro and in vivo through EMT and cytoskeleton reconstruction.

Fig. 7

A Migration in S26 and 6–10B cells transfected with NDRG1 or vector control (n = 4 independent experiments). B Migration in S18 and 5–8F cells transfected with shNDRG1 or shscramble (n = 4 independent experiments). C Metastasis and invasion in S26 and 6–10B cells transfected with NDRG1 or control (n = 4 independent experiments). D Metastasis and invasion in S18, and 5–8F cells transfected with shNDRG1 or shscramble (n = 4 independent experiments). E N-cadherin, E-cadherin, Snail, and vimentin expressions in the cells transfected with vector, NDRG1, shscramble or shNDRG1. F F-actin formation of the cells transfected with vector, NDRG1, shscramble or shNDRG1. Scale bars, 10 μm. G, I The metastases of nude mice injected with the cells upregulated or downregulated NDRG1 by luciferase-based bioluminescence imaging. H, J IHC staining of EMT markers in the xenograft tumors. Scale bars, 100 μm. Data are expressed as mean ± SEM; *P < 0.05, **P < 0.01, ***P < 0.001.